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Page 1
A proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom-Up and Top-Down approaches.
Scott L, Eskes C, Hoffmann S, Adriaens E, Alepée N, Bufo M, Clothier R, Facchini D, Faller C, Guest R, Harbell J, Hartung T, Kamp H, Varlet BL, Meloni M, McNamee P, Osborne R, Pape W, Pfannenbecker U, Prinsen M, Seaman C, Spielmann H, Stokes W, Trouba K, Berghe CV, Goethem FV, Vassallo M, Vinardell P, Zuang V. Scott L, et al. Among authors: spielmann h. Toxicol In Vitro. 2010 Feb;24(1):1-9. doi: 10.1016/j.tiv.2009.05.019. Epub 2009 May 31. Toxicol In Vitro. 2010. PMID: 19490935 Review.
The ECVAM international validation study on in vitro tests for acute skin irritation: report on the validity of the EPISKIN and EpiDerm assays and on the Skin Integrity Function Test.
Spielmann H, Hoffmann S, Liebsch M, Botham P, Fentem JH, Eskes C, Roguet R, Cotovio J, Cole T, Worth A, Heylings J, Jones P, Robles C, Kandárová H, Gamer A, Remmele M, Curren R, Raabe H, Cockshott A, Gerner I, Zuang V. Spielmann H, et al. Altern Lab Anim. 2007 Dec;35(6):559-601. doi: 10.1177/026119290703500614. Altern Lab Anim. 2007. PMID: 18186667
The principles of weight of evidence validation of test methods and testing strategies. The report and recommendations of ECVAM workshop 58.
Balls M, Amcoff P, Bremer S, Casati S, Coecke S, Clothier R, Combes R, Corvi R, Curren R, Eskes C, Fentem J, Gribaldo L, Halder M, Hartung T, Hoffmann S, Schectman L, Scott L, Spielmann H, Stokes W, Tice R, Wagner D, Zuang V; ECVAM. Balls M, et al. Among authors: spielmann h. Altern Lab Anim. 2006 Dec;34(6):603-20. doi: 10.1177/026119290603400604. Altern Lab Anim. 2006. PMID: 17266393 Free PMC article. No abstract available.
The International EU/COLIPA In Vitro Phototoxicity Validation Study: Results of Phase II (Blind Trial). Part 1: The 3T3 NRU Phototoxicity Test.
Spielmann H, Balls M, Dupuis J, Pape WJ, Pechovitch G, de Silva O, Holzhütter HG, Clothier R, Desolle P, Gerberick F, Liebsch M, Lovell WW, Maurer T, Pfannenbecker U, Potthast JM, Csato M, Sladowski D, Steiling W, Brantom P. Spielmann H, et al. Toxicol In Vitro. 1998 Jun 1;12(3):305-27. doi: 10.1016/s0887-2333(98)00006-x. Toxicol In Vitro. 1998. PMID: 20654413
The sophisticated process of validation.
Hartung T, Spielmann H. Hartung T, et al. Among authors: spielmann h. ALTEX. 1995;12(2):98-103. ALTEX. 1995. PMID: 11178424 English.
Validation-Lessons learned from practical experience.
Fentem JH, Prinsen MK, Spielmann H, Walum E, Botham PA. Fentem JH, et al. Among authors: spielmann h. Toxicol In Vitro. 1995 Dec;9(6):857-62. Toxicol In Vitro. 1995. PMID: 20650167
Assessment of the human epidermis model SkinEthic RHE for in vitro skin corrosion testing of chemicals according to new OECD TG 431.
Kandárová H, Liebsch M, Spielmann H, Genschow E, Schmidt E, Traue D, Guest R, Whittingham A, Warren N, Gamer AO, Remmele M, Kaufmann T, Wittmer E, De Wever B, Rosdy M. Kandárová H, et al. Among authors: spielmann h. Toxicol In Vitro. 2006 Aug;20(5):547-59. doi: 10.1016/j.tiv.2005.11.008. Epub 2006 Feb 7. Toxicol In Vitro. 2006. PMID: 16455230
297 results