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Variation of the aryl substituent on the piperazine ring within the 4-(piperazin-1-yl)-2,6-di(pyrrolidin-1-yl)pyrimidine scaffold unveils potent, non-competitive inhibitors of the inflammatory caspases.
Kent CR, Bryja M, Gustafson HA, Kawarski MY, Lenti G, Pierce EN, Knopp RC, Ceja V, Pati B, Walters DE, Karver CE. Kent CR, et al. Among authors: walters de. Bioorg Med Chem Lett. 2016 Nov 15;26(22):5476-5480. doi: 10.1016/j.bmcl.2016.10.025. Epub 2016 Oct 12. Bioorg Med Chem Lett. 2016. PMID: 27777011
146 results