Solit DB - Search Results

1

The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers.

Veeriah S, Brennan C, Meng S, Singh B, Fagin JA, Solit DB, Paty PB, Rohle D, Vivanco I, Chmielecki J, Pao W, Ladanyi M, Gerald WL, Liau L, Cloughesy TC, Mischel PS, Sander C, Taylor B, Schultz N, Major J, Heguy A, Fang F, Mellinghoff IK, Chan TA. Veeriah S, et al. Among authors: solit db. Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9435-40. doi: 10.1073/pnas.0900571106. Epub 2009 May 28. Proc Natl Acad Sci U S A. 2009. PMID: 19478061 Free PMC article.

2

Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2/neu-dependent breast tumors.

de Candia P, Solit DB, Giri D, Brogi E, Siegel PM, Olshen AB, Muller WJ, Rosen N, Benezra R. de Candia P, et al. Among authors: solit db. Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12337-42. doi: 10.1073/pnas.2031337100. Epub 2003 Oct 2. Proc Natl Acad Sci U S A. 2003. PMID: 14526102 Free PMC article.

3

V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors.

Grbovic OM, Basso AD, Sawai A, Ye Q, Friedlander P, Solit D, Rosen N. Grbovic OM, et al. Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):57-62. doi: 10.1073/pnas.0609973103. Epub 2005 Dec 21. Proc Natl Acad Sci U S A. 2006. PMID: 16371460 Free PMC article.

4

Development of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitors.

Regales L, Balak MN, Gong Y, Politi K, Sawai A, Le C, Koutcher JA, Solit DB, Rosen N, Zakowski MF, Pao W. Regales L, et al. Among authors: solit db. PLoS One. 2007 Aug 29;2(8):e810. doi: 10.1371/journal.pone.0000810. PLoS One. 2007. PMID: 17726540 Free PMC article.

5

BRAFV600E mutation is associated with preferential sensitivity to mitogen-activated protein kinase kinase inhibition in thyroid cancer cell lines.

Leboeuf R, Baumgartner JE, Benezra M, Malaguarnera R, Solit D, Pratilas CA, Rosen N, Knauf JA, Fagin JA. Leboeuf R, et al. J Clin Endocrinol Metab. 2008 Jun;93(6):2194-201. doi: 10.1210/jc.2007-2825. Epub 2008 Apr 1. J Clin Endocrinol Metab. 2008. PMID: 18381570 Free PMC article.

6

Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinoma.

Marks JL, Gong Y, Chitale D, Golas B, McLellan MD, Kasai Y, Ding L, Mardis ER, Wilson RK, Solit D, Levine R, Michel K, Thomas RK, Rusch VW, Ladanyi M, Pao W. Marks JL, et al. Cancer Res. 2008 Jul 15;68(14):5524-8. doi: 10.1158/0008-5472.CAN-08-0099. Cancer Res. 2008. PMID: 18632602 Free PMC article.

7

Genetic predictors of MEK dependence in non-small cell lung cancer.

Pratilas CA, Hanrahan AJ, Halilovic E, Persaud Y, Soh J, Chitale D, Shigematsu H, Yamamoto H, Sawai A, Janakiraman M, Taylor BS, Pao W, Toyooka S, Ladanyi M, Gazdar A, Rosen N, Solit DB. Pratilas CA, et al. Among authors: solit db. Cancer Res. 2008 Nov 15;68(22):9375-83. doi: 10.1158/0008-5472.CAN-08-2223. Cancer Res. 2008. PMID: 19010912 Free PMC article.

8

(V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway.

Pratilas CA, Taylor BS, Ye Q, Viale A, Sander C, Solit DB, Rosen N. Pratilas CA, et al. Among authors: solit db. Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4519-24. doi: 10.1073/pnas.0900780106. Epub 2009 Feb 27. Proc Natl Acad Sci U S A. 2009. PMID: 19251651 Free PMC article.

9

Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1.

Ricarte-Filho JC, Ryder M, Chitale DA, Rivera M, Heguy A, Ladanyi M, Janakiraman M, Solit D, Knauf JA, Tuttle RM, Ghossein RA, Fagin JA. Ricarte-Filho JC, et al. Cancer Res. 2009 Jun 1;69(11):4885-93. doi: 10.1158/0008-5472.CAN-09-0727. Cancer Res. 2009. PMID: 19487299 Free PMC article.

10

PIK3CA mutation associates with improved outcome in breast cancer.

Kalinsky K, Jacks LM, Heguy A, Patil S, Drobnjak M, Bhanot UK, Hedvat CV, Traina TA, Solit D, Gerald W, Moynahan ME. Kalinsky K, et al. Clin Cancer Res. 2009 Aug 15;15(16):5049-59. doi: 10.1158/1078-0432.CCR-09-0632. Epub 2009 Aug 11. Clin Cancer Res. 2009. PMID: 19671852

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