Howes A - Search Results

1

Critical role for caspase-8 in epidermal growth factor signaling.

Finlay D, Howes A, Vuori K. Finlay D, et al. Among authors: howes a. Cancer Res. 2009 Jun 15;69(12):5023-9. doi: 10.1158/0008-5472.CAN-08-3731. Epub 2009 May 26. Cancer Res. 2009. PMID: 19470771 Free PMC article.

2

Novel HTS strategy identifies TRAIL-sensitizing compounds acting specifically through the caspase-8 apoptotic axis.

Finlay D, Richardson RD, Landberg LK, Howes AL, Vuori K. Finlay D, et al. PLoS One. 2010 Oct 12;5(10):e13375. doi: 10.1371/journal.pone.0013375. PLoS One. 2010. PMID: 20967281 Free PMC article.

3

Caspase-8 as a potential mediator of pro-tumorigenic signals.

Finlay D, Howes A, Vuori K. Finlay D, et al. Among authors: howes a. Cell Cycle. 2009 Nov 1;8(21):3441-2. doi: 10.4161/cc.8.21.9649. Epub 2009 Nov 29. Cell Cycle. 2009. PMID: 19838056 No abstract available.

4

The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures.

Howes AL, Chiang GG, Lang ES, Ho CB, Powis G, Vuori K, Abraham RT. Howes AL, et al. Mol Cancer Ther. 2007 Sep;6(9):2505-14. doi: 10.1158/1535-7163.MCT-06-0698. Epub 2007 Aug 31. Mol Cancer Ther. 2007. PMID: 17766839

5

3-Dimensional culture systems for anti-cancer compound profiling and high-throughput screening reveal increases in EGFR inhibitor-mediated cytotoxicity compared to monolayer culture systems.

Howes AL, Richardson RD, Finlay D, Vuori K. Howes AL, et al. PLoS One. 2014 Sep 23;9(9):e108283. doi: 10.1371/journal.pone.0108283. eCollection 2014. PLoS One. 2014. PMID: 25247711 Free PMC article.

6

Antitumor activity of rapamycin in a transgenic mouse model of ErbB2-dependent human breast cancer.

Liu M, Howes A, Lesperance J, Stallcup WB, Hauser CA, Kadoya K, Oshima RG, Abraham RT. Liu M, et al. Among authors: howes a. Cancer Res. 2005 Jun 15;65(12):5325-36. doi: 10.1158/0008-5472.CAN-04-4589. Cancer Res. 2005. PMID: 15958580

7

Increased expression and activity of RhoA are associated with increased DNA synthesis and reduced p27(Kip1) expression in the vasculature of hypertensive rats.

Seasholtz TM, Zhang T, Morissette MR, Howes AL, Yang AH, Brown JH. Seasholtz TM, et al. Among authors: howes al. Circ Res. 2001 Sep 14;89(6):488-95. doi: 10.1161/hh1801.096337. Circ Res. 2001. PMID: 11557735

8

Galphaq expression activates EGFR and induces Akt mediated cardiomyocyte survival: dissociation from Galphaq mediated hypertrophy.

Howes AL, Miyamoto S, Adams JW, Woodcock EA, Brown JH. Howes AL, et al. J Mol Cell Cardiol. 2006 May;40(5):597-604. doi: 10.1016/j.yjmcc.2005.12.003. Epub 2006 Feb 8. J Mol Cell Cardiol. 2006. PMID: 16466740

9

Akt-mediated cardiomyocyte survival pathways are compromised by G alpha q-induced phosphoinositide 4,5-bisphosphate depletion.

Howes AL, Arthur JF, Zhang T, Miyamoto S, Adams JW, Dorn GW 2nd, Woodcock EA, Brown JH. Howes AL, et al. J Biol Chem. 2003 Oct 10;278(41):40343-51. doi: 10.1074/jbc.M305964200. Epub 2003 Aug 4. J Biol Chem. 2003. PMID: 12900409 Free article.

10

Ca2+ dysregulation induces mitochondrial depolarization and apoptosis: role of Na+/Ca2+ exchanger and AKT.

Miyamoto S, Howes AL, Adams JW, Dorn GW 2nd, Brown JH. Miyamoto S, et al. J Biol Chem. 2005 Nov 18;280(46):38505-12. doi: 10.1074/jbc.M505223200. Epub 2005 Aug 1. J Biol Chem. 2005. PMID: 16061478 Free article.

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