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FGF-21/FGF-21 receptor interaction and activation is determined by betaKlotho.
Kharitonenkov A, Dunbar JD, Bina HA, Bright S, Moyers JS, Zhang C, Ding L, Micanovic R, Mehrbod SF, Knierman MD, Hale JE, Coskun T, Shanafelt AB. Kharitonenkov A, et al. Among authors: shanafelt ab. J Cell Physiol. 2008 Apr;215(1):1-7. doi: 10.1002/jcp.21357. J Cell Physiol. 2008. PMID: 18064602
FGF-21 as a novel metabolic regulator.
Kharitonenkov A, Shiyanova TL, Koester A, Ford AM, Micanovic R, Galbreath EJ, Sandusky GE, Hammond LJ, Moyers JS, Owens RA, Gromada J, Brozinick JT, Hawkins ED, Wroblewski VJ, Li DS, Mehrbod F, Jaskunas SR, Shanafelt AB. Kharitonenkov A, et al. Among authors: shanafelt ab. J Clin Invest. 2005 Jun;115(6):1627-35. doi: 10.1172/JCI23606. Epub 2005 May 2. J Clin Invest. 2005. PMID: 15902306 Free PMC article.
Receptor-based design of cytokine therapeutics.
Shanafelt AB. Shanafelt AB. Curr Pharm Biotechnol. 2003 Feb;4(1):1-20. doi: 10.2174/1389201033378066. Curr Pharm Biotechnol. 2003. PMID: 12570679 Review.
Enhancing exposure of protein therapeutics.
Beals JM, Shanafelt AB. Beals JM, et al. Among authors: shanafelt ab. Drug Discov Today Technol. 2006 Spring;3(1):87-94. doi: 10.1016/j.ddtec.2006.03.001. Drug Discov Today Technol. 2006. PMID: 24980106
A T-cell-selective interleukin 2 mutein exhibits potent antitumor activity and is well tolerated in vivo.
Shanafelt AB, Lin Y, Shanafelt MC, Forte CP, Dubois-Stringfellow N, Carter C, Gibbons JA, Cheng SL, Delaria KA, Fleischer R, Greve JM, Gundel R, Harris K, Kelly R, Koh B, Li Y, Lantz L, Mak P, Neyer L, Plym MJ, Roczniak S, Serban D, Thrift J, Tsuchiyama L, Wetzel M, Wong M, Zolotorev A. Shanafelt AB, et al. Among authors: shanafelt mc. Nat Biotechnol. 2000 Nov;18(11):1197-202. doi: 10.1038/81199. Nat Biotechnol. 2000. PMID: 11062441
Therapeutic enhancement of IL-2 through molecular design.
Cassell DJ, Choudhri S, Humphrey R, Martell RE, Reynolds T, Shanafelt AB. Cassell DJ, et al. Among authors: shanafelt ab. Curr Pharm Des. 2002;8(24):2171-83. doi: 10.2174/1381612023393260. Curr Pharm Des. 2002. PMID: 12369861 Review.
27 results