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662 results

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Page 1
Discovery of tetrasubstituted imidazolines as potent and selective neuropeptide Y Y5 receptor antagonists: reduced human ether-a-go-go related gene potassium channel binding affinity and potent antiobesity effect.
Sato N, Ando M, Ishikawa S, Jitsuoka M, Nagai K, Takahashi H, Sakuraba A, Tsuge H, Kitazawa H, Iwaasa H, Mashiko S, Gomori A, Moriya R, Fujino N, Ohe T, Ishihara A, Kanatani A, Fukami T. Sato N, et al. Among authors: fukami t. J Med Chem. 2009 May 28;52(10):3385-96. doi: 10.1021/jm900110t. J Med Chem. 2009. PMID: 19459652
A neuropeptide Y Y5 antagonist selectively ameliorates body weight gain and associated parameters in diet-induced obese mice.
Ishihara A, Kanatani A, Mashiko S, Tanaka T, Hidaka M, Gomori A, Iwaasa H, Murai N, Egashira S, Murai T, Mitobe Y, Matsushita H, Okamoto O, Sato N, Jitsuoka M, Fukuroda T, Ohe T, Guan X, MacNeil DJ, Van der Ploeg LH, Nishikibe M, Ishii Y, Ihara M, Fukami T. Ishihara A, et al. Among authors: fukami t. Proc Natl Acad Sci U S A. 2006 May 2;103(18):7154-8. doi: 10.1073/pnas.0510320103. Epub 2006 Apr 24. Proc Natl Acad Sci U S A. 2006. PMID: 16636293 Free PMC article.
A pair-feeding study reveals that a Y5 antagonist causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure.
Mashiko S, Ishihara A, Iwaasa H, Sano H, Ito J, Gomori A, Oda Z, Moriya R, Matsushita H, Jitsuoka M, Okamoto O, MacNeil DJ, Van der Ploeg LH, Fukami T, Kanatani A. Mashiko S, et al. Among authors: fukami t. Mol Pharmacol. 2007 Feb;71(2):602-8. doi: 10.1124/mol.106.029991. Epub 2006 Nov 14. Mol Pharmacol. 2007. PMID: 17105869
Effects of a novel Y5 antagonist in obese mice: combination with food restriction or sibutramine.
Mashiko S, Ishihara A, Iwaasa H, Moriya R, Kitazawa H, Mitobe Y, Ito J, Gomori A, Matsushita H, Takahashi T, MacNeil DJ, Van der Ploeg LH, Fukami T, Kanatani A. Mashiko S, et al. Among authors: fukami t. Obesity (Silver Spring). 2008 Jul;16(7):1510-5. doi: 10.1038/oby.2008.223. Epub 2008 Apr 10. Obesity (Silver Spring). 2008. PMID: 18421274 Free article.
Synthesis, structure-activity relationships, and biological profiles of a quinazolinone class of histamine H3 receptor inverse agonists.
Nagase T, Mizutani T, Ishikawa S, Sekino E, Sasaki T, Fujimura T, Ito S, Mitobe Y, Miyamoto Y, Yoshimoto R, Tanaka T, Ishihara A, Takenaga N, Tokita S, Fukami T, Sato N. Nagase T, et al. Among authors: fukami t. J Med Chem. 2008 Aug 14;51(15):4780-9. doi: 10.1021/jm8003834. Epub 2008 Jul 4. J Med Chem. 2008. PMID: 18598020
(9S)-9-(2-hydroxy-4,4-dimethyl-6-oxo-1-cyclohexen-1-yl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-xanthen-1-one, a selective and orally active neuropeptide Y Y5 receptor antagonist.
Sato N, Jitsuoka M, Shibata T, Hirohashi T, Nonoshita K, Moriya M, Haga Y, Sakuraba A, Ando M, Ohe T, Iwaasa H, Gomori A, Ishihara A, Kanatani A, Fukami T. Sato N, et al. Among authors: fukami t. J Med Chem. 2008 Aug 14;51(15):4765-70. doi: 10.1021/jm8003587. Epub 2008 Jul 19. J Med Chem. 2008. PMID: 18637668
662 results