LaPointe P - Search Results

1

Hsp90 regulates the function of argonaute 2 and its recruitment to stress granules and P-bodies.

Pare JM, Tahbaz N, López-Orozco J, LaPointe P, Lasko P, Hobman TC. Pare JM, et al. Among authors: lapointe p. Mol Biol Cell. 2009 Jul;20(14):3273-84. doi: 10.1091/mbc.e09-01-0082. Epub 2009 May 20. Mol Biol Cell. 2009. PMID: 19458189 Free PMC article.

2

Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis.

Wang X, Venable J, LaPointe P, Hutt DM, Koulov AV, Coppinger J, Gurkan C, Kellner W, Matteson J, Plutner H, Riordan JR, Kelly JW, Yates JR 3rd, Balch WE. Wang X, et al. Among authors: lapointe p. Cell. 2006 Nov 17;127(4):803-15. doi: 10.1016/j.cell.2006.09.043. Cell. 2006. PMID: 17110338 Free article.

3

Biological and structural basis for Aha1 regulation of Hsp90 ATPase activity in maintaining proteostasis in the human disease cystic fibrosis.

Koulov AV, LaPointe P, Lu B, Razvi A, Coppinger J, Dong MQ, Matteson J, Laister R, Arrowsmith C, Yates JR 3rd, Balch WE. Koulov AV, et al. Among authors: lapointe p. Mol Biol Cell. 2010 Mar 15;21(6):871-84. doi: 10.1091/mbc.e09-12-1017. Epub 2010 Jan 20. Mol Biol Cell. 2010. PMID: 20089831 Free PMC article.

4

Fluorine- and rhenium-containing geldanamycin derivatives as leads for the development of molecular probes for imaging Hsp90.

Wuest F, Bouvet V, Mai B, LaPointe P. Wuest F, et al. Among authors: lapointe p. Org Biomol Chem. 2012 Sep 7;10(33):6724-31. doi: 10.1039/c2ob25744k. Epub 2012 Jul 24. Org Biomol Chem. 2012. PMID: 22825378

5

The co-chaperone Hch1 regulates Hsp90 function differently than its homologue Aha1 and confers sensitivity to yeast to the Hsp90 inhibitor NVP-AUY922.

Armstrong H, Wolmarans A, Mercier R, Mai B, LaPointe P. Armstrong H, et al. Among authors: lapointe p. PLoS One. 2012;7(11):e49322. doi: 10.1371/journal.pone.0049322. Epub 2012 Nov 14. PLoS One. 2012. PMID: 23166640 Free PMC article.

6

Hsp90 cochaperones p23 and FKBP4 physically interact with hAgo2 and activate RNA interference-mediated silencing in mammalian cells.

Pare JM, LaPointe P, Hobman TC. Pare JM, et al. Among authors: lapointe p. Mol Biol Cell. 2013 Aug;24(15):2303-10. doi: 10.1091/mbc.E12-12-0892. Epub 2013 Jun 5. Mol Biol Cell. 2013. PMID: 23741051 Free PMC article.

7

Regulation of RNA interference by Hsp90 is an evolutionarily conserved process.

Wang Y, Mercier R, Hobman TC, LaPointe P. Wang Y, et al. Among authors: lapointe p. Biochim Biophys Acta. 2013 Dec;1833(12):2673-2681. doi: 10.1016/j.bbamcr.2013.06.017. Epub 2013 Jul 1. Biochim Biophys Acta. 2013. PMID: 23827255 Free article.

8

A mutation in the catalytic loop of Hsp90 specifically impairs ATPase stimulation by Aha1p, but not Hch1p.

Horvat NK, Armstrong H, Lee BL, Mercier R, Wolmarans A, Knowles J, Spyracopoulos L, LaPointe P. Horvat NK, et al. Among authors: lapointe p. J Mol Biol. 2014 Jun 12;426(12):2379-92. doi: 10.1016/j.jmb.2014.04.002. Epub 2014 Apr 12. J Mol Biol. 2014. PMID: 24726918

9

The diverse roles of Hsp90 and where to find them.

Van Oosten-Hawle P, Bolon DN, LaPointe P. Van Oosten-Hawle P, et al. Among authors: lapointe p. Nat Struct Mol Biol. 2017 Jan 5;24(1):1-4. doi: 10.1038/nsmb.3359. Nat Struct Mol Biol. 2017. PMID: 28054566 No abstract available.

10

Aha-type co-chaperones: the alpha or the omega of the Hsp90 ATPase cycle?

LaPointe P, Mercier R, Wolmarans A. LaPointe P, et al. Biol Chem. 2020 Mar 26;401(4):423-434. doi: 10.1515/hsz-2019-0341. Biol Chem. 2020. PMID: 31782942 Free article. Review.

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