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HIV infection of dendritic cells subverts the IFN induction pathway via IRF-1 and inhibits type 1 IFN production.
Harman AN, Lai J, Turville S, Samarajiwa S, Gray L, Marsden V, Mercier SK, Jones K, Nasr N, Rustagi A, Cumming H, Donaghy H, Mak J, Gale M Jr, Churchill M, Hertzog P, Cunningham AL. Harman AN, et al. Among authors: mercier sk. Blood. 2011 Jul 14;118(2):298-308. doi: 10.1182/blood-2010-07-297721. Epub 2011 Mar 16. Blood. 2011. PMID: 21411754 Free PMC article.
The microvesicle component of HIV-1 inocula modulates dendritic cell infection and maturation and enhances adhesion to and activation of T lymphocytes.
Mercier SK, Donaghy H, Botting RA, Turville SG, Harman AN, Nasr N, Ji H, Kusebauch U, Mendoza L, Shteynberg D, Sandgren K, Simpson RJ, Moritz RL, Cunningham AL. Mercier SK, et al. PLoS Pathog. 2013 Oct;9(10):e1003700. doi: 10.1371/journal.ppat.1003700. Epub 2013 Oct 17. PLoS Pathog. 2013. PMID: 24204260 Free PMC article.