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Validation of a voltage-sensitive dye (di-4-ANEPPS)-based method for assessing drug-induced delayed repolarisation in beagle dog left ventricular midmyocardial myocytes.
Hardy ME, Pollard CE, Small BG, Bridgland-Taylor M, Woods AJ, Valentin JP, Abi-Gerges N. Hardy ME, et al. Among authors: valentin jp. J Pharmacol Toxicol Methods. 2009 Jul-Aug;60(1):94-106. doi: 10.1016/j.vascn.2009.03.005. Epub 2009 May 4. J Pharmacol Toxicol Methods. 2009. PMID: 19414070
Nonclinical proarrhythmia models: predicting Torsades de Pointes.
Lawrence CL, Pollard CE, Hammond TG, Valentin JP. Lawrence CL, et al. Among authors: valentin jp. J Pharmacol Toxicol Methods. 2005 Jul-Aug;52(1):46-59. doi: 10.1016/j.vascn.2005.04.011. J Pharmacol Toxicol Methods. 2005. PMID: 15975832 Review.
Gender differences in the slow delayed (IKs) but not in inward (IK1) rectifier K+ currents of canine Purkinje fibre cardiac action potential: key roles for IKs, beta-adrenoceptor stimulation, pacing rate and gender.
Abi-Gerges N, Small BG, Lawrence CL, Hammond TG, Valentin JP, Pollard CE. Abi-Gerges N, et al. Among authors: valentin jp. Br J Pharmacol. 2006 Mar;147(6):653-60. doi: 10.1038/sj.bjp.0706491. Br J Pharmacol. 2006. PMID: 16314855 Free PMC article.
A framework to assess the translation of safety pharmacology data to humans.
Valentin JP, Bialecki R, Ewart L, Hammond T, Leishmann D, Lindgren S, Martinez V, Pollard C, Redfern W, Wallis R. Valentin JP, et al. J Pharmacol Toxicol Methods. 2009 Sep-Oct;60(2):152-8. doi: 10.1016/j.vascn.2009.05.011. Epub 2009 Jul 17. J Pharmacol Toxicol Methods. 2009. PMID: 19616110
The application of in vitro methods to safety pharmacology.
Wakefield ID, Pollard C, Redfern WS, Hammond TG, Valentin JP. Wakefield ID, et al. Among authors: valentin jp. Fundam Clin Pharmacol. 2002 Jun;16(3):209-18. doi: 10.1046/j.1472-8206.2002.00099.x. Fundam Clin Pharmacol. 2002. PMID: 12165068 Review.
204 results