Mazhab-Jafari MT - Search Results

1

Dynamically driven ligand selectivity in cyclic nucleotide binding domains.

Das R, Chowdhury S, Mazhab-Jafari MT, Sildas S, Selvaratnam R, Melacini G. Das R, et al. J Biol Chem. 2009 Aug 28;284(35):23682-96. doi: 10.1074/jbc.M109.011700. Epub 2009 Apr 29. J Biol Chem. 2009. PMID: 19403523 Free PMC article.

2

Understanding cAMP-dependent allostery by NMR spectroscopy: comparative analysis of the EPAC1 cAMP-binding domain in its apo and cAMP-bound states.

Mazhab-Jafari MT, Das R, Fotheringham SA, SilDas S, Chowdhury S, Melacini G. Mazhab-Jafari MT, et al. J Am Chem Soc. 2007 Nov 21;129(46):14482-92. doi: 10.1021/ja0753703. Epub 2007 Oct 31. J Am Chem Soc. 2007. PMID: 17973384

3

Entropy-driven cAMP-dependent allosteric control of inhibitory interactions in exchange proteins directly activated by cAMP.

Das R, Mazhab-Jafari MT, Chowdhury S, SilDas S, Selvaratnam R, Melacini G. Das R, et al. J Biol Chem. 2008 Jul 11;283(28):19691-703. doi: 10.1074/jbc.M802164200. Epub 2008 Apr 14. J Biol Chem. 2008. PMID: 18411261 Free article.

4

The projection analysis of NMR chemical shifts reveals extended EPAC autoinhibition determinants.

Selvaratnam R, VanSchouwen B, Fogolari F, Mazhab-Jafari MT, Das R, Melacini G. Selvaratnam R, et al. Biophys J. 2012 Feb 8;102(3):630-9. doi: 10.1016/j.bpj.2011.12.030. Epub 2012 Feb 7. Biophys J. 2012. PMID: 22325287 Free PMC article.

5

The auto-inhibitory role of the EPAC hinge helix as mapped by NMR.

Selvaratnam R, Mazhab-Jafari MT, Das R, Melacini G. Selvaratnam R, et al. PLoS One. 2012;7(11):e48707. doi: 10.1371/journal.pone.0048707. Epub 2012 Nov 21. PLoS One. 2012. PMID: 23185272 Free PMC article.

6

Label-free assay for thermodynamic analysis of protein-ligand interactions: a multivariate strategy for allosteric ligand screening.

Gavina JM, Mazhab-Jafari MT, Melacini G, Britz-McKibbin P. Gavina JM, et al. Biochemistry. 2009 Jan 20;48(2):223-5. doi: 10.1021/bi802121g. Biochemistry. 2009. PMID: 19113833

7

Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR).

Mazhab-Jafari MT, Marshall CB, Ho J, Ishiyama N, Stambolic V, Ikura M. Mazhab-Jafari MT, et al. J Biol Chem. 2014 May 2;289(18):12195-201. doi: 10.1074/jbc.C113.543736. Epub 2014 Mar 19. J Biol Chem. 2014. PMID: 24648513 Free PMC article.

8

Real-time NMR study of three small GTPases reveals that fluorescent 2'(3')-O-(N-methylanthraniloyl)-tagged nucleotides alter hydrolysis and exchange kinetics.

Mazhab-Jafari MT, Marshall CB, Smith M, Gasmi-Seabrook GM, Stambolic V, Rottapel R, Neel BG, Ikura M. Mazhab-Jafari MT, et al. J Biol Chem. 2010 Feb 19;285(8):5132-6. doi: 10.1074/jbc.C109.064766. Epub 2009 Dec 14. J Biol Chem. 2010. PMID: 20018863 Free PMC article.

9

Biochemical Classification of Disease-associated Mutants of RAS-like Protein Expressed in Many Tissues (RIT1).

Fang Z, Marshall CB, Yin JC, Mazhab-Jafari MT, Gasmi-Seabrook GM, Smith MJ, Nishikawa T, Xu Y, Neel BG, Ikura M. Fang Z, et al. J Biol Chem. 2016 Jul 22;291(30):15641-52. doi: 10.1074/jbc.M116.714196. Epub 2016 May 18. J Biol Chem. 2016. PMID: 27226556 Free PMC article.

10

Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.

Mazhab-Jafari MT, Marshall CB, Smith MJ, Gasmi-Seabrook GM, Stathopulos PB, Inagaki F, Kay LE, Neel BG, Ikura M. Mazhab-Jafari MT, et al. Proc Natl Acad Sci U S A. 2015 May 26;112(21):6625-30. doi: 10.1073/pnas.1419895112. Epub 2015 May 4. Proc Natl Acad Sci U S A. 2015. PMID: 25941399 Free PMC article.

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