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Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain.
Ahn K, Johnson DS, Mileni M, Beidler D, Long JZ, McKinney MK, Weerapana E, Sadagopan N, Liimatta M, Smith SE, Lazerwith S, Stiff C, Kamtekar S, Bhattacharya K, Zhang Y, Swaney S, Van Becelaere K, Stevens RC, Cravatt BF. Ahn K, et al. Among authors: long jz. Chem Biol. 2009 Apr 24;16(4):411-20. doi: 10.1016/j.chembiol.2009.02.013. Chem Biol. 2009. PMID: 19389627 Free PMC article.
Reversible competitive α-ketoheterocycle inhibitors of fatty acid amide hydrolase containing additional conformational constraints in the acyl side chain: orally active, long-acting analgesics.
Ezzili C, Mileni M, McGlinchey N, Long JZ, Kinsey SG, Hochstatter DG, Stevens RC, Lichtman AH, Cravatt BF, Bilsky EJ, Boger DL. Ezzili C, et al. Among authors: long jz. J Med Chem. 2011 Apr 28;54(8):2805-22. doi: 10.1021/jm101597x. Epub 2011 Mar 23. J Med Chem. 2011. PMID: 21428410 Free PMC article.
Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling.
Pan B, Wang W, Long JZ, Sun D, Hillard CJ, Cravatt BF, Liu QS. Pan B, et al. Among authors: long jz. J Pharmacol Exp Ther. 2009 Nov;331(2):591-7. doi: 10.1124/jpet.109.158162. Epub 2009 Aug 7. J Pharmacol Exp Ther. 2009. PMID: 19666749 Free PMC article.
87 results