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AP23846, a novel and highly potent Src family kinase inhibitor, reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogates downstream angiogenic processes.
Summy JM, Trevino JG, Lesslie DP, Baker CH, Shakespeare WC, Wang Y, Sundaramoorthi R, Metcalf CA 3rd, Keats JA, Sawyer TK, Gallick GE. Summy JM, et al. Among authors: lesslie dp. Mol Cancer Ther. 2005 Dec;4(12):1900-11. doi: 10.1158/1535-7163.MCT-05-0171. Mol Cancer Ther. 2005. PMID: 16373705
Src activation of Stat3 is an independent requirement from NF-kappaB activation for constitutive IL-8 expression in human pancreatic adenocarcinoma cells.
Trevino JG, Gray MJ, Nawrocki ST, Summy JM, Lesslie DP, Evans DB, Sawyer TK, Shakespeare WC, Watowich SS, Chiao PJ, McConkey DJ, Gallick GE. Trevino JG, et al. Among authors: lesslie dp. Angiogenesis. 2006;9(2):101-10. doi: 10.1007/s10456-006-9038-9. Epub 2006 Jul 27. Angiogenesis. 2006. PMID: 16871430