Hepcidin bound to α2-macroglobulin reduces ferroportin-1 expression and enhances its activity at reducing serum iron levels.
Huang ML, Austin CJD, Sari MA, Suryo Rahmanto Y, Ponka P, Vyoral D, Richardson DR.
Huang ML, et al. Among authors: ponka p.
J Biol Chem. 2013 Aug 30;288(35):25450-25465. doi: 10.1074/jbc.M113.471573. Epub 2013 Jul 11.
J Biol Chem. 2013.
PMID: 23846698
Free PMC article.
We demonstrated that hepcidin is complexed to the blood transport protein, alpha2-macroglobulin (alpha2M) (Peslova, G., Petrak, J., Kuzelova, K., Hrdy, I., Halada, P., Kuchel, P. W., Soe-Lin, S., Ponka, P., Sutak, R., Becker, E., Huang, M. L., Suryo Ra …
We demonstrated that hepcidin is complexed to the blood transport protein, alpha2-macroglobulin (alpha2M) (Peslova, G., Petrak, J., Kuzelova …