Lowther J - Search Results

1

The external aldimine form of serine palmitoyltransferase: structural, kinetic, and spectroscopic analysis of the wild-type enzyme and HSAN1 mutant mimics.

Raman MCC, Johnson KA, Yard BA, Lowther J, Carter LG, Naismith JH, Campopiano DJ. Raman MCC, et al. Among authors: lowther j. J Biol Chem. 2009 Jun 19;284(25):17328-17339. doi: 10.1074/jbc.M109.008680. Epub 2009 Apr 17. J Biol Chem. 2009. PMID: 19376777 Free PMC article.

2

The chemical basis of serine palmitoyltransferase inhibition by myriocin.

Wadsworth JM, Clarke DJ, McMahon SA, Lowther JP, Beattie AE, Langridge-Smith PR, Broughton HB, Dunn TM, Naismith JH, Campopiano DJ. Wadsworth JM, et al. Among authors: lowther jp. J Am Chem Soc. 2013 Sep 25;135(38):14276-85. doi: 10.1021/ja4059876. Epub 2013 Sep 11. J Am Chem Soc. 2013. PMID: 23957439 Free article.

3

Inhibition of the PLP-dependent enzyme serine palmitoyltransferase by cycloserine: evidence for a novel decarboxylative mechanism of inactivation.

Lowther J, Yard BA, Johnson KA, Carter LG, Bhat VT, Raman MC, Clarke DJ, Ramakers B, McMahon SA, Naismith JH, Campopiano DJ. Lowther J, et al. Mol Biosyst. 2010 Sep;6(9):1682-93. doi: 10.1039/c003743e. Epub 2010 May 5. Mol Biosyst. 2010. PMID: 20445930 Free PMC article.

4

Role of a conserved arginine residue during catalysis in serine palmitoyltransferase.

Lowther J, Charmier G, Raman MC, Ikushiro H, Hayashi H, Campopiano DJ. Lowther J, et al. FEBS Lett. 2011 Jun 23;585(12):1729-34. doi: 10.1016/j.febslet.2011.04.013. Epub 2011 Apr 18. FEBS Lett. 2011. PMID: 21514297 Free article.

5

Structural, mechanistic and regulatory studies of serine palmitoyltransferase.

Lowther J, Naismith JH, Dunn TM, Campopiano DJ. Lowther J, et al. Biochem Soc Trans. 2012 Jun 1;40(3):547-54. doi: 10.1042/BST20110769. Biochem Soc Trans. 2012. PMID: 22616865 Free article. Review.

6

Reconstitution of the pyridoxal 5'-phosphate (PLP) dependent enzyme serine palmitoyltransferase (SPT) with pyridoxal reveals a crucial role for the phosphate during catalysis.

Beattie AE, Clarke DJ, Wadsworth JM, Lowther J, Sin HL, Campopiano DJ. Beattie AE, et al. Among authors: lowther j. Chem Commun (Camb). 2013 Aug 14;49(63):7058-60. doi: 10.1039/c3cc43001d. Chem Commun (Camb). 2013. PMID: 23814788 Free article.

7

Characterization of homologous sphingosine-1-phosphate lyase isoforms in the bacterial pathogen Burkholderia pseudomallei.

McLean CJ, Marles-Wright J, Custodio R, Lowther J, Kennedy AJ, Pollock J, Clarke DJ, Brown AR, Campopiano DJ. McLean CJ, et al. Among authors: lowther j. J Lipid Res. 2017 Jan;58(1):137-150. doi: 10.1194/jlr.M071258. Epub 2016 Oct 26. J Lipid Res. 2017. PMID: 27784725 Free PMC article.

8

Triazole biotin: a tight-binding biotinidase-resistant conjugate.

Germeroth AI, Hanna JR, Karim R, Kundel F, Lowther J, Neate PG, Blackburn EA, Wear MA, Campopiano DJ, Hulme AN. Germeroth AI, et al. Among authors: lowther j. Org Biomol Chem. 2013 Nov 28;11(44):7700-4. doi: 10.1039/c3ob41837e. Epub 2013 Oct 10. Org Biomol Chem. 2013. PMID: 24108311

9

Characterization of secreted sphingosine-1-phosphate lyases required for virulence and intracellular survival of Burkholderia pseudomallei.

Custódio R, McLean CJ, Scott AE, Lowther J, Kennedy A, Clarke DJ, Campopiano DJ, Sarkar-Tyson M, Brown AR. Custódio R, et al. Among authors: lowther j. Mol Microbiol. 2016 Dec;102(6):1004-1019. doi: 10.1111/mmi.13531. Epub 2016 Sep 26. Mol Microbiol. 2016. PMID: 27632710 Free article.

10

Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica.

Stack CM, Caffrey CR, Donnelly SM, Seshaadri A, Lowther J, Tort JF, Collins PR, Robinson MW, Xu W, McKerrow JH, Craik CS, Geiger SR, Marion R, Brinen LS, Dalton JP. Stack CM, et al. Among authors: lowther j. J Biol Chem. 2008 Apr 11;283(15):9896-908. doi: 10.1074/jbc.M708521200. Epub 2007 Dec 26. J Biol Chem. 2008. PMID: 18160404 Free PMC article.

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