Subramanian R - Search Results

1

In vitro metabolism of the novel, highly selective oral angiogenesis inhibitor motesanib diphosphate in preclinical species and in humans.

Li C, Kuchimanchi M, Hickman D, Poppe L, Hayashi M, Zhou Y, Subramanian R, Kumar G, Surapaneni S. Li C, et al. Among authors: subramanian r. Drug Metab Dispos. 2009 Jul;37(7):1378-94. doi: 10.1124/dmd.108.025742. Epub 2009 Apr 16. Drug Metab Dispos. 2009. PMID: 19372226

2

Cytochrome P450-mediated epoxidation of 2-aminothiazole-based AKT inhibitors: identification of novel GSH adducts and reduction of metabolic activation through structural changes guided by in silico and in vitro screening.

Subramanian R, Lee MR, Allen JG, Bourbeau MP, Fotsch C, Hong FT, Tadesse S, Yao G, Yuan CC, Surapaneni S, Skiles GL, Wang X, Wohlhieter GE, Zeng Q, Zhou Y, Zhu X, Li C. Subramanian R, et al. Chem Res Toxicol. 2010 Mar 15;23(3):653-63. doi: 10.1021/tx900414g. Chem Res Toxicol. 2010. PMID: 20095585

3

Biosynthesis of drug metabolites using microbes in hollow fiber cartridge reactors: case study of diclofenac metabolism by Actinoplanes species.

Osorio-Lozada A, Surapaneni S, Skiles GL, Subramanian R. Osorio-Lozada A, et al. Among authors: subramanian r. Drug Metab Dispos. 2008 Feb;36(2):234-40. doi: 10.1124/dmd.107.019323. Epub 2007 Nov 15. Drug Metab Dispos. 2008. PMID: 18006646

4

Enhanced detection and characterization of glutathione-trapped reactive metabolites by pseudo-MS(3) transition using a linear ion trap mass spectrometer.

Zhu X, Hayashi M, Subramanian R. Zhu X, et al. Among authors: subramanian r. Chem Res Toxicol. 2012 Sep 17;25(9):1839-41. doi: 10.1021/tx300339u. Epub 2012 Aug 30. Chem Res Toxicol. 2012. PMID: 22920186

5

Activity-based exposure comparisons among humans and nonclinical safety testing species in an extensively metabolized drug candidate.

Zhu X, Slatter JG, Emery MG, Deane MR, Akrami A, Zhang X, Hickman D, Skiles GL, Subramanian R. Zhu X, et al. Among authors: subramanian r. Xenobiotica. 2013 Jul;43(7):617-27. doi: 10.3109/00498254.2012.747711. Epub 2012 Dec 17. Xenobiotica. 2013. PMID: 23244593

6

Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization.

Prueksaritanont T, Subramanian R, Fang X, Ma B, Qiu Y, Lin JH, Pearson PG, Baillie TA. Prueksaritanont T, et al. Among authors: subramanian r. Drug Metab Dispos. 2002 May;30(5):505-12. doi: 10.1124/dmd.30.5.505. Drug Metab Dispos. 2002. PMID: 11950779

7

Sequential metabolism of AMG 487, a novel CXCR3 antagonist, results in formation of quinone reactive metabolites that covalently modify CYP3A4 Cys239 and cause time-dependent inhibition of the enzyme.

Henne KR, Tran TB, VandenBrink BM, Rock DA, Aidasani DK, Subramanian R, Mason AK, Stresser DM, Teffera Y, Wong SG, Johnson MG, Chen X, Tonn GR, Wong BK. Henne KR, et al. Among authors: subramanian r. Drug Metab Dispos. 2012 Jul;40(7):1429-40. doi: 10.1124/dmd.112.045708. Epub 2012 Apr 19. Drug Metab Dispos. 2012. PMID: 22517972

8

Effects of fibrates on metabolism of statins in human hepatocytes.

Prueksaritanont T, Tang C, Qiu Y, Mu L, Subramanian R, Lin JH. Prueksaritanont T, et al. Among authors: subramanian r. Drug Metab Dispos. 2002 Nov;30(11):1280-7. doi: 10.1124/dmd.30.11.1280. Drug Metab Dispos. 2002. PMID: 12386136

9

Regiospecific and stereospecific triangulation of the structures of metabolites formed by sequential metabolism at multiple prochiral centers.

Greene RJ, Davis JA, Subramanian R, Deane MR, Emery MG, Slatter JG. Greene RJ, et al. Among authors: subramanian r. Drug Metab Dispos. 2012 May;40(5):928-42. doi: 10.1124/dmd.111.043166. Epub 2012 Feb 10. Drug Metab Dispos. 2012. PMID: 22328582

10

Structural characterization of novel adenine dinucleotide phosphate conjugates of imatinib in incubations with rat and human liver microsomes.

Ma S, Subramanian R, Xu Y, Schrag M, Shou M. Ma S, et al. Among authors: subramanian r. Drug Metab Dispos. 2008 Dec;36(12):2414-8. doi: 10.1124/dmd.108.023085. Epub 2008 Sep 17. Drug Metab Dispos. 2008. PMID: 18799804

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