Al-Hashimi H - Search Results

1

Amphipathic small molecules mimic the binding mode and function of endogenous transcription factors.

Buhrlage SJ, Bates CA, Rowe SP, Minter AR, Brennan BB, Majmudar CY, Wemmer DE, Al-Hashimi H, Mapp AK. Buhrlage SJ, et al. ACS Chem Biol. 2009 May 15;4(5):335-44. doi: 10.1021/cb900028j. ACS Chem Biol. 2009. PMID: 19348463 Free PMC article.

2

Discovery of selective bioactive small molecules by targeting an RNA dynamic ensemble.

Stelzer AC, Frank AT, Kratz JD, Swanson MD, Gonzalez-Hernandez MJ, Lee J, Andricioaei I, Markovitz DM, Al-Hashimi HM. Stelzer AC, et al. Nat Chem Biol. 2011 Jun 26;7(8):553-9. doi: 10.1038/nchembio.596. Nat Chem Biol. 2011. PMID: 21706033 Free PMC article.

3

Manipulating unconventional CH-based hydrogen bonding in a methyltransferase via noncanonical amino acid mutagenesis.

Horowitz S, Adhikari U, Dirk LM, Del Rizzo PA, Mehl RA, Houtz RL, Al-Hashimi HM, Scheiner S, Trievel RC. Horowitz S, et al. ACS Chem Biol. 2014 Aug 15;9(8):1692-7. doi: 10.1021/cb5001185. Epub 2014 Jul 3. ACS Chem Biol. 2014. PMID: 24914947

4

Dynamics-based amplification of RNA function and its characterization by using NMR spectroscopy.

Al-Hashimi HM. Al-Hashimi HM. Chembiochem. 2005 Sep;6(9):1506-19. doi: 10.1002/cbic.200500002. Chembiochem. 2005. PMID: 16138302 Review.

5

Modulating protein structure with fluorous amino acids: increased stability and native-like structure conferred on a 4-helix bundle protein by hexafluoroleucine.

Lee HY, Lee KH, Al-Hashimi HM, Marsh EN. Lee HY, et al. J Am Chem Soc. 2006 Jan 11;128(1):337-43. doi: 10.1021/ja0563410. J Am Chem Soc. 2006. PMID: 16390163

6

Dynamics of large elongated RNA by NMR carbon relaxation.

Hansen AL, Al-Hashimi HM. Hansen AL, et al. J Am Chem Soc. 2007 Dec 26;129(51):16072-82. doi: 10.1021/ja0757982. Epub 2007 Nov 30. J Am Chem Soc. 2007. PMID: 18047338

7

NMR studies of an immunomodulatory benzodiazepine binding to its molecular target on the mitochondrial F(1)F(0)-ATPase.

Stelzer AC, Frazee RW, Van Huis C, Cleary J, Opipari AW Jr, Glick GD, Al-Hashimi HM. Stelzer AC, et al. Biopolymers. 2010 Jan;93(1):85-92. doi: 10.1002/bip.21306. Biopolymers. 2010. PMID: 19768783 Free article.

8

A rare example of lock-and-key RNA recognition.

Dethoff EA, Al-Hashimi HM. Dethoff EA, et al. J Mol Biol. 2010 Dec 10;404(4):553-4. doi: 10.1016/j.jmb.2010.10.014. Epub 2010 Oct 15. J Mol Biol. 2010. PMID: 20951707 No abstract available.

9

Sequence-specific B-DNA flexibility modulates Z-DNA formation.

Bothe JR, Lowenhaupt K, Al-Hashimi HM. Bothe JR, et al. J Am Chem Soc. 2011 Feb 23;133(7):2016-8. doi: 10.1021/ja1073068. Epub 2011 Jan 28. J Am Chem Soc. 2011. PMID: 21275369 Free PMC article.

10

Conservation and functional importance of carbon-oxygen hydrogen bonding in AdoMet-dependent methyltransferases.

Horowitz S, Dirk LM, Yesselman JD, Nimtz JS, Adhikari U, Mehl RA, Scheiner S, Houtz RL, Al-Hashimi HM, Trievel RC. Horowitz S, et al. J Am Chem Soc. 2013 Oct 16;135(41):15536-48. doi: 10.1021/ja407140k. Epub 2013 Oct 7. J Am Chem Soc. 2013. PMID: 24093804

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