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Characterization of the potent and highly selective A2A receptor antagonists preladenant and SCH 412348 [7-[2-[4-2,4-difluorophenyl]-1-piperazinyl]ethyl]-2-(2-furanyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine] in rodent models of movement disorders and depression.
Hodgson RA, Bertorelli R, Varty GB, Lachowicz JE, Forlani A, Fredduzzi S, Cohen-Williams ME, Higgins GA, Impagnatiello F, Nicolussi E, Parra LE, Foster C, Zhai Y, Neustadt BR, Stamford AW, Parker EM, Reggiani A, Hunter JC. Hodgson RA, et al. Among authors: stamford aw. J Pharmacol Exp Ther. 2009 Jul;330(1):294-303. doi: 10.1124/jpet.108.149617. Epub 2009 Mar 30. J Pharmacol Exp Ther. 2009. PMID: 19332567
Potent, selective, and orally active adenosine A2A receptor antagonists: arylpiperazine derivatives of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines.
Neustadt BR, Hao J, Lindo N, Greenlee WJ, Stamford AW, Tulshian D, Ongini E, Hunter J, Monopoli A, Bertorelli R, Foster C, Arik L, Lachowicz J, Ng K, Feng KI. Neustadt BR, et al. Among authors: stamford aw. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1376-80. doi: 10.1016/j.bmcl.2006.11.083. Epub 2006 Dec 3. Bioorg Med Chem Lett. 2007. PMID: 17236762
Potent and selective adenosine A2A receptor antagonists: 1,2,4-Triazolo[1,5-c]pyrimidines.
Neustadt BR, Liu H, Hao J, Greenlee WJ, Stamford AW, Foster C, Arik L, Lachowicz J, Zhang H, Bertorelli R, Fredduzzi S, Varty G, Cohen-Williams M, Ng K. Neustadt BR, et al. Among authors: stamford aw. Bioorg Med Chem Lett. 2009 Feb 1;19(3):967-71. doi: 10.1016/j.bmcl.2008.11.075. Epub 2008 Nov 24. Bioorg Med Chem Lett. 2009. PMID: 19109019
Tetrahydroquinoline sulfonamides as vasopressin 1b receptor antagonists.
Scott JD, Miller MW, Li SW, Lin SI, Vaccaro HA, Hong L, Mullins DE, Guzzi M, Weinstein J, Hodgson RA, Varty GB, Stamford AW, Chan TY, McKittrick BA, Greenlee WJ, Priestley T, Parker EM. Scott JD, et al. Among authors: stamford aw. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6018-22. doi: 10.1016/j.bmcl.2009.09.050. Epub 2009 Sep 17. Bioorg Med Chem Lett. 2009. PMID: 19800231
61 results