Anderson AC - Search Results

1

The solution structure of Bacillus anthracis dihydrofolate reductase yields insight into the analysis of structure-activity relationships for novel inhibitors.

Beierlein JM, Deshmukh L, Frey KM, Vinogradova O, Anderson AC. Beierlein JM, et al. Among authors: anderson ac. Biochemistry. 2009 May 19;48(19):4100-8. doi: 10.1021/bi802319w. Biochemistry. 2009. PMID: 19323450 Free PMC article.

2

Structure-based approach to the development of potent and selective inhibitors of dihydrofolate reductase from cryptosporidium.

Bolstad DB, Bolstad ES, Frey KM, Wright DL, Anderson AC. Bolstad DB, et al. Among authors: anderson ac. J Med Chem. 2008 Nov 13;51(21):6839-52. doi: 10.1021/jm8009124. Epub 2008 Oct 4. J Med Chem. 2008. PMID: 18834108 Free PMC article.

3

Synthetic and crystallographic studies of a new inhibitor series targeting Bacillus anthracis dihydrofolate reductase.

Beierlein JM, Frey KM, Bolstad DB, Pelphrey PM, Joska TM, Smith AE, Priestley ND, Wright DL, Anderson AC. Beierlein JM, et al. Among authors: anderson ac. J Med Chem. 2008 Dec 11;51(23):7532-40. doi: 10.1021/jm800776a. J Med Chem. 2008. PMID: 19007108 Free PMC article.

4

Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance.

Frey KM, Liu J, Lombardo MN, Bolstad DB, Wright DL, Anderson AC. Frey KM, et al. Among authors: anderson ac. J Mol Biol. 2009 Apr 17;387(5):1298-308. doi: 10.1016/j.jmb.2009.02.045. Epub 2009 Feb 26. J Mol Biol. 2009. PMID: 19249312 Free PMC article.

5

Towards the understanding of resistance mechanisms in clinically isolated trimethoprim-resistant, methicillin-resistant Staphylococcus aureus dihydrofolate reductase.

Frey KM, Lombardo MN, Wright DL, Anderson AC. Frey KM, et al. Among authors: anderson ac. J Struct Biol. 2010 Apr;170(1):93-7. doi: 10.1016/j.jsb.2009.12.011. Epub 2009 Dec 21. J Struct Biol. 2010. PMID: 20026215 Free PMC article.

6

Targeted mutations of Bacillus anthracis dihydrofolate reductase condense complex structure−activity relationships.

Beierlein JM, Karri NG, Anderson AC. Beierlein JM, et al. Among authors: anderson ac. J Med Chem. 2010 Oct 28;53(20):7327-36. doi: 10.1021/jm100727t. J Med Chem. 2010. PMID: 20882962 Free PMC article.

7

Prospective screening of novel antibacterial inhibitors of dihydrofolate reductase for mutational resistance.

Frey KM, Viswanathan K, Wright DL, Anderson AC. Frey KM, et al. Among authors: anderson ac. Antimicrob Agents Chemother. 2012 Jul;56(7):3556-62. doi: 10.1128/AAC.06263-11. Epub 2012 Apr 9. Antimicrob Agents Chemother. 2012. PMID: 22491688 Free PMC article.

8

New developments in vaccines, inhibitors of anthrax toxins, and antibiotic therapeutics for Bacillus anthracis.

Beierlein JM, Anderson AC. Beierlein JM, et al. Among authors: anderson ac. Curr Med Chem. 2011;18(33):5083-94. doi: 10.2174/092986711797636036. Curr Med Chem. 2011. PMID: 22050756 Free PMC article. Review.

9

Predicting resistance mutations using protein design algorithms.

Frey KM, Georgiev I, Donald BR, Anderson AC. Frey KM, et al. Among authors: anderson ac. Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13707-12. doi: 10.1073/pnas.1002162107. Epub 2010 Jul 19. Proc Natl Acad Sci U S A. 2010. PMID: 20643959 Free PMC article.

10

Protein design algorithms predict viable resistance to an experimental antifolate.

Reeve SM, Gainza P, Frey KM, Georgiev I, Donald BR, Anderson AC. Reeve SM, et al. Among authors: anderson ac. Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):749-54. doi: 10.1073/pnas.1411548112. Epub 2014 Dec 31. Proc Natl Acad Sci U S A. 2015. PMID: 25552560 Free PMC article.

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