De Strooper B - Search Results

1

gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease.

Serneels L, Van Biervliet J, Craessaerts K, Dejaegere T, Horré K, Van Houtvin T, Esselmann H, Paul S, Schäfer MK, Berezovska O, Hyman BT, Sprangers B, Sciot R, Moons L, Jucker M, Yang Z, May PC, Karran E, Wiltfang J, D'Hooge R, De Strooper B. Serneels L, et al. Among authors: de strooper b. Science. 2009 May 1;324(5927):639-42. doi: 10.1126/science.1171176. Epub 2009 Mar 19. Science. 2009. PMID: 19299585 Free PMC article.

2

Molecular cloning of the mouse gene coding for alpha 2-macroglobulin and targeting of the gene in embryonic stem cells.

Umans L, Serneels L, Hilliker C, Stas L, Overbergh L, De Strooper B, Van Leuven F, Van den Berghe H. Umans L, et al. Among authors: de strooper b. Genomics. 1994 Aug;22(3):519-29. doi: 10.1006/geno.1994.1425. Genomics. 1994. PMID: 7528166

3

Structure of the gene (LRP1) coding for the human alpha 2-macroglobulin receptor lipoprotein receptor-related protein.

Van Leuven F, Stas L, Hilliker C, Lorent K, Umans L, Serneels L, Overbergh L, Torrekens S, Moechars D, De Strooper B, et al. Van Leuven F, et al. Among authors: de strooper b. Genomics. 1994 Nov 1;24(1):78-89. doi: 10.1006/geno.1994.1584. Genomics. 1994. PMID: 7534747

4

Cloning, characterization, and chromosomal localization to 4p16 of the human gene (LRPAP1) coding for the alpha 2-macroglobulin receptor-associated protein and structural comparison with the murine gene coding for the 44-kDa heparin-binding protein.

Van Leuven F, Hilliker C, Serneels L, Umans L, Overbergh L, De Strooper B, Fryns JP, Van den Berghe H. Van Leuven F, et al. Among authors: de strooper b. Genomics. 1995 Jan 20;25(2):492-500. doi: 10.1016/0888-7543(95)80050-v. Genomics. 1995. PMID: 7789983

5

Basolateral secretion of amyloid precursor protein in Madin-Darby canine kidney cells is disturbed by alterations of intracellular pH and by introducing a mutation associated with familial Alzheimer's disease.

De Strooper B, Craessaerts K, Dewachter I, Moechars D, Greenberg B, Van Leuven F, Van den Berghe H. De Strooper B, et al. J Biol Chem. 1995 Feb 24;270(8):4058-65. doi: 10.1074/jbc.270.8.4058. J Biol Chem. 1995. PMID: 7876155 Free article.

6

Exchanging the extracellular domain of amyloid precursor protein for horseradish peroxidase does not interfere with alpha-secretase cleavage of the beta-amyloid region, but randomizes secretion in Madin-Darby canine kidney cells.

De Strooper B, Craessaerts K, Van Leuven F, Van Den Berghe H. De Strooper B, et al. J Biol Chem. 1995 Dec 22;270(51):30310-4. doi: 10.1074/jbc.270.51.30310. J Biol Chem. 1995. PMID: 8530453 Free article.

7

Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D.

Saftig P, Peters C, von Figura K, Craessaerts K, Van Leuven F, De Strooper B. Saftig P, et al. Among authors: de strooper b. J Biol Chem. 1996 Nov 1;271(44):27241-4. doi: 10.1074/jbc.271.44.27241. J Biol Chem. 1996. PMID: 8910296 Free article.

8

Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

De Strooper B, Beullens M, Contreras B, Levesque L, Craessaerts K, Cordell B, Moechars D, Bollen M, Fraser P, George-Hyslop PS, Van Leuven F. De Strooper B, et al. J Biol Chem. 1997 Feb 7;272(6):3590-8. doi: 10.1074/jbc.272.6.3590. J Biol Chem. 1997. PMID: 9013610 Free article.

9

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein.

De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, Annaert W, Von Figura K, Van Leuven F. De Strooper B, et al. Nature. 1998 Jan 22;391(6665):387-90. doi: 10.1038/34910. Nature. 1998. PMID: 9450754

10

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.

De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R. De Strooper B, et al. Nature. 1999 Apr 8;398(6727):518-22. doi: 10.1038/19083. Nature. 1999. PMID: 10206645

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