Webster R - Search Results

1

Prediction of human pharmacokinetics from preclinical information: comparative accuracy of quantitative prediction approaches.

Hosea NA, Collard WT, Cole S, Maurer TS, Fang RX, Jones H, Kakar SM, Nakai Y, Smith BJ, Webster R, Beaumont K. Hosea NA, et al. Among authors: webster r. J Clin Pharmacol. 2009 May;49(5):513-33. doi: 10.1177/0091270009333209. Epub 2009 Mar 19. J Clin Pharmacol. 2009. PMID: 19299532

2

Impact of physicochemical and structural properties on the pharmacokinetics of a series of alpha1L-adrenoceptor antagonists.

Betts A, Atkinson F, Gardner I, Fox D, Webster R, Beaumont K, Morgan P. Betts A, et al. Among authors: webster r. Drug Metab Dispos. 2007 Aug;35(8):1435-45. doi: 10.1124/dmd.107.015180. Epub 2007 May 14. Drug Metab Dispos. 2007. PMID: 17502340 Clinical Trial.

3

Clinical Micro-Dose Studies to Explore the Human Pharmacokinetics of Four Selective Inhibitors of Human Nav1.7 Voltage-Dependent Sodium Channels.

Jones HM, Butt RP, Webster RW, Gurrell I, Dzygiel P, Flanagan N, Fraier D, Hay T, Iavarone LE, Luckwell J, Pearce H, Phipps A, Segelbacher J, Speed B, Beaumont K. Jones HM, et al. Clin Pharmacokinet. 2016 Jul;55(7):875-887. doi: 10.1007/s40262-015-0365-0. Clin Pharmacokinet. 2016. PMID: 26895021 Clinical Trial.

4

Use of modelling and simulation techniques to support decision making on the progression of PF-04878691, a TLR7 agonist being developed for hepatitis C.

Jones HM, Chan PL, van der Graaf PH, Webster R. Jones HM, et al. Among authors: webster r. Br J Clin Pharmacol. 2012 Jan;73(1):77-92. doi: 10.1111/j.1365-2125.2011.04047.x. Br J Clin Pharmacol. 2012. PMID: 21689140 Free PMC article.

5

Pre-clinical pharmacokinetics of UK-453,061, a novel non-nucleoside reverse transcriptase inhibitor (NNRTI), and use of in silico physiologically based prediction tools to predict the oral pharmacokinetics of UK-453,061 in man.

Allan G, Davis J, Dickins M, Gardner I, Jenkins T, Jones H, Webster R, Westgate H. Allan G, et al. Among authors: webster r. Xenobiotica. 2008 Jun;38(6):620-40. doi: 10.1080/00498250802069088. Xenobiotica. 2008. PMID: 18570162

6

A Physiologically-Based Pharmacokinetic Model for the Prediction of Monoclonal Antibody Pharmacokinetics From In Vitro Data.

Jones HM, Zhang Z, Jasper P, Luo H, Avery LB, King LE, Neubert H, Barton HA, Betts AM, Webster R. Jones HM, et al. Among authors: webster r. CPT Pharmacometrics Syst Pharmacol. 2019 Oct;8(10):738-747. doi: 10.1002/psp4.12461. Epub 2019 Sep 23. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 31464379 Free PMC article.

7

Design of ester prodrugs to enhance oral absorption of poorly permeable compounds: challenges to the discovery scientist.

Beaumont K, Webster R, Gardner I, Dack K. Beaumont K, et al. Among authors: webster r. Curr Drug Metab. 2003 Dec;4(6):461-85. doi: 10.2174/1389200033489253. Curr Drug Metab. 2003. PMID: 14683475 Review.

8

A Physiologically-Based Pharmacokinetic Model for the Prediction of "Half-Life Extension" and "Catch and Release" Monoclonal Antibody Pharmacokinetics.

Jones HM, Tolsma J, Zhang Z, Jasper P, Luo H, Weber GL, Wright K, Bard J, Bell R, Messing D, Kelleher K, Piche-Nicholas N, Webster R. Jones HM, et al. Among authors: webster r. CPT Pharmacometrics Syst Pharmacol. 2020 Sep;9(9):534-541. doi: 10.1002/psp4.12547. Epub 2020 Aug 17. CPT Pharmacometrics Syst Pharmacol. 2020. PMID: 32697437 Free PMC article.

9

Pharmacokinetics and disposition of a novel NMDA glycine site antagonist (UK-240,455) in rats, dogs and man.

Webster R, Cole S, Gedge J, Roffey S, Walker D, Wild W. Webster R, et al. Xenobiotica. 2003 May;33(5):541-60. doi: 10.1080/0049825031000085988. Xenobiotica. 2003. PMID: 12746109

10

Pharmacokinetics and clearance processes of UK-279,276 (rNIF) in rat and dog: comparison with human data.

Webster R, Edgington A, Phipps J, Walker D. Webster R, et al. Xenobiotica. 2006 Apr;36(4):341-9. doi: 10.1080/00498250600630941. Xenobiotica. 2006. PMID: 16684713

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