High KA - Search Results

1

Protein replacement therapy and gene transfer in canine models of hemophilia A, hemophilia B, von willebrand disease, and factor VII deficiency.

Nichols TC, Dillow AM, Franck HW, Merricks EP, Raymer RA, Bellinger DA, Arruda VR, High KA. Nichols TC, et al. Among authors: high ka. ILAR J. 2009;50(2):144-67. doi: 10.1093/ilar.50.2.144. ILAR J. 2009. PMID: 19293459 Free PMC article. Review.

2

ARFI ultrasound monitoring of hemorrhage and hemostasis in vivo in canine von Willebrand disease and hemophilia.

Scola MR, Nichols TC, Zhu H, Caughey MC, Merricks EP, Raymer RA, Margaritis P, High KA, Gallippi CM. Scola MR, et al. Among authors: high ka. Ultrasound Med Biol. 2011 Dec;37(12):2126-32. doi: 10.1016/j.ultrasmedbio.2011.09.006. Epub 2011 Oct 26. Ultrasound Med Biol. 2011. PMID: 22033127 Free PMC article.

3

Translational data from adeno-associated virus-mediated gene therapy of hemophilia B in dogs.

Nichols TC, Whitford MH, Arruda VR, Stedman HH, Kay MA, High KA. Nichols TC, et al. Among authors: high ka. Hum Gene Ther Clin Dev. 2015 Mar;26(1):5-14. doi: 10.1089/humc.2014.153. Epub 2015 Feb 12. Hum Gene Ther Clin Dev. 2015. PMID: 25675273 Free PMC article. Review.

4

Sustained correction of FVII deficiency in dogs using AAV-mediated expression of zymogen FVII.

Marcos-Contreras OA, Smith SM, Bellinger DA, Raymer RA, Merricks E, Faella A, Pavani G, Zhou S, Nichols TC, High KA, Margaritis P. Marcos-Contreras OA, et al. Among authors: high ka. Blood. 2016 Feb 4;127(5):565-71. doi: 10.1182/blood-2015-09-671420. Epub 2015 Dec 23. Blood. 2016. PMID: 26702064 Free PMC article.

5

Prevention of spontaneous bleeding in dogs with haemophilia A and haemophilia B.

Nichols TC, Raymer RA, Franck HW, Merricks EP, Bellinger DA, DeFriess N, Margaritis P, Arruda VR, Kay MA, High KA. Nichols TC, et al. Among authors: high ka. Haemophilia. 2010 May;16 Suppl 3(Suppl 3):19-23. doi: 10.1111/j.1365-2516.2010.02255.x. Haemophilia. 2010. PMID: 20586797 Free PMC article. Review.

6

Sustained phenotypic correction of hemophilia B dogs with a factor IX null mutation by liver-directed gene therapy.

Mount JD, Herzog RW, Tillson DM, Goodman SA, Robinson N, McCleland ML, Bellinger D, Nichols TC, Arruda VR, Lothrop CD Jr, High KA. Mount JD, et al. Among authors: high ka. Blood. 2002 Apr 15;99(8):2670-6. doi: 10.1182/blood.v99.8.2670. Blood. 2002. PMID: 11929752 Free article.

7

Influence of vector dose on factor IX-specific T and B cell responses in muscle-directed gene therapy.

Herzog RW, Fields PA, Arruda VR, Brubaker JO, Armstrong E, McClintock D, Bellinger DA, Couto LB, Nichols TC, High KA. Herzog RW, et al. Among authors: high ka. Hum Gene Ther. 2002 Jul 20;13(11):1281-91. doi: 10.1089/104303402760128513. Hum Gene Ther. 2002. PMID: 12162811

8

Safety and efficacy of factor IX gene transfer to skeletal muscle in murine and canine hemophilia B models by adeno-associated viral vector serotype 1.

Arruda VR, Schuettrumpf J, Herzog RW, Nichols TC, Robinson N, Lotfi Y, Mingozzi F, Xiao W, Couto LB, High KA. Arruda VR, et al. Among authors: high ka. Blood. 2004 Jan 1;103(1):85-92. doi: 10.1182/blood-2003-05-1446. Epub 2003 Sep 11. Blood. 2004. PMID: 12969984 Free PMC article.

9

Successful treatment of canine hemophilia by continuous expression of canine FVIIa.

Margaritis P, Roy E, Aljamali MN, Downey HD, Giger U, Zhou S, Merricks E, Dillow A, Ezban M, Nichols TC, High KA. Margaritis P, et al. Among authors: high ka. Blood. 2009 Apr 16;113(16):3682-9. doi: 10.1182/blood-2008-07-168377. Epub 2008 Dec 23. Blood. 2009. PMID: 19109232 Free PMC article.

10

Peripheral transvenular delivery of adeno-associated viral vectors to skeletal muscle as a novel therapy for hemophilia B.

Arruda VR, Stedman HH, Haurigot V, Buchlis G, Baila S, Favaro P, Chen Y, Franck HG, Zhou S, Wright JF, Couto LB, Jiang H, Pierce GF, Bellinger DA, Mingozzi F, Nichols TC, High KA. Arruda VR, et al. Among authors: high ka. Blood. 2010 Jun 10;115(23):4678-88. doi: 10.1182/blood-2009-12-261156. Epub 2010 Mar 24. Blood. 2010. PMID: 20335222 Free PMC article.

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