Joseph RE - Search Results

1

Conformational snapshots of Tec kinases during signaling.

Joseph RE, Andreotti AH. Joseph RE, et al. Immunol Rev. 2009 Mar;228(1):74-92. doi: 10.1111/j.1600-065X.2008.00740.x. Immunol Rev. 2009. PMID: 19290922 Free PMC article.

2

The linker between SH2 and kinase domains positively regulates catalysis of the Tec family kinases.

Joseph RE, Min L, Andreotti AH. Joseph RE, et al. Biochemistry. 2007 May 8;46(18):5455-62. doi: 10.1021/bi602512e. Epub 2007 Apr 11. Biochemistry. 2007. PMID: 17425330 Free article.

3

A remote substrate docking mechanism for the tec family tyrosine kinases.

Joseph RE, Min L, Xu R, Musselman ED, Andreotti AH. Joseph RE, et al. Biochemistry. 2007 May 8;46(18):5595-603. doi: 10.1021/bi700127c. Epub 2007 Apr 17. Biochemistry. 2007. PMID: 17439160 Free article.

4

Mechanism and functional significance of Itk autophosphorylation.

Joseph RE, Fulton DB, Andreotti AH. Joseph RE, et al. J Mol Biol. 2007 Nov 9;373(5):1281-92. doi: 10.1016/j.jmb.2007.08.060. Epub 2007 Aug 31. J Mol Biol. 2007. PMID: 17897671 Free PMC article.

5

Bacterial expression and purification of interleukin-2 tyrosine kinase: single step separation of the chaperonin impurity.

Joseph RE, Andreotti AH. Joseph RE, et al. Protein Expr Purif. 2008 Aug;60(2):194-7. doi: 10.1016/j.pep.2008.04.001. Epub 2008 Apr 11. Protein Expr Purif. 2008. PMID: 18495488 Free PMC article.

6

Proline isomerization preorganizes the Itk SH2 domain for binding to the Itk SH3 domain.

Severin A, Joseph RE, Boyken S, Fulton DB, Andreotti AH. Severin A, et al. Among authors: joseph re. J Mol Biol. 2009 Apr 3;387(3):726-43. doi: 10.1016/j.jmb.2009.02.012. Epub 2009 Feb 12. J Mol Biol. 2009. PMID: 19361414 Free PMC article.

7

SH2-dependent autophosphorylation within the Tec family kinase Itk.

Joseph RE, Severin A, Min L, Fulton DB, Andreotti AH. Joseph RE, et al. J Mol Biol. 2009 Aug 7;391(1):164-77. doi: 10.1016/j.jmb.2009.06.023. Epub 2009 Jun 11. J Mol Biol. 2009. PMID: 19523959 Free PMC article.

8

Itk tyrosine kinase substrate docking is mediated by a nonclassical SH2 domain surface of PLCgamma1.

Min L, Joseph RE, Fulton DB, Andreotti AH. Min L, et al. Among authors: joseph re. Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21143-8. doi: 10.1073/pnas.0911309106. Epub 2009 Dec 1. Proc Natl Acad Sci U S A. 2009. PMID: 19955438 Free PMC article.

9

Disrupting the intermolecular self-association of Itk enhances T cell signaling.

Min L, Wu W, Joseph RE, Fulton DB, Berg L, Andreotti AH. Min L, et al. Among authors: joseph re. J Immunol. 2010 Apr 15;184(8):4228-35. doi: 10.4049/jimmunol.0901908. Epub 2010 Mar 17. J Immunol. 2010. PMID: 20237289 Free PMC article.

10

T-cell signaling regulated by the Tec family kinase, Itk.

Andreotti AH, Schwartzberg PL, Joseph RE, Berg LJ. Andreotti AH, et al. Among authors: joseph re. Cold Spring Harb Perspect Biol. 2010 Jul;2(7):a002287. doi: 10.1101/cshperspect.a002287. Epub 2010 Jun 2. Cold Spring Harb Perspect Biol. 2010. PMID: 20519342 Free PMC article. Review.

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