Middleton SA - Search Results

1

Synthesis and evaluation of 2,7-diamino-thiazolo[4,5-d] pyrimidine analogues as anti-tumor epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors.

Lin R, Johnson SG, Connolly PJ, Wetter SK, Binnun E, Hughes TV, Murray WV, Pandey NB, Moreno-Mazza SJ, Adams M, Fuentes-Pesquera AR, Middleton SA. Lin R, et al. Among authors: middleton sa. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2333-7. doi: 10.1016/j.bmcl.2009.02.067. Epub 2009 Feb 21. Bioorg Med Chem Lett. 2009. PMID: 19286381

2

Synthesis and evaluation of N-acyl sulfonamides as potential prodrugs of cyclin-dependent kinase inhibitor JNJ-7706621.

Huang S, Connolly PJ, Lin R, Emanuel S, Middleton SA. Huang S, et al. Among authors: middleton sa. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3639-41. doi: 10.1016/j.bmcl.2006.04.071. Epub 2006 May 6. Bioorg Med Chem Lett. 2006. PMID: 16682186

3

Synthesis and discovery of macrocyclic polyoxygenated bis-7-azaindolylmaleimides as a novel series of potent and highly selective glycogen synthase kinase-3beta inhibitors.

Kuo GH, Prouty C, DeAngelis A, Shen L, O'Neill DJ, Shah C, Connolly PJ, Murray WV, Conway BR, Cheung P, Westover L, Xu JZ, Look RA, Demarest KT, Emanuel S, Middleton SA, Jolliffe L, Beavers MP, Chen X. Kuo GH, et al. Among authors: middleton sa. J Med Chem. 2003 Sep 11;46(19):4021-31. doi: 10.1021/jm030115o. J Med Chem. 2003. PMID: 12954055

4

Synthesis and discovery of pyrazine-pyridine biheteroaryl as a novel series of potent vascular endothelial growth factor receptor-2 inhibitors.

Kuo GH, Wang A, Emanuel S, Deangelis A, Zhang R, Connolly PJ, Murray WV, Gruninger RH, Sechler J, Fuentes-Pesquera A, Johnson D, Middleton SA, Jolliffe L, Chen X. Kuo GH, et al. Among authors: middleton sa. J Med Chem. 2005 Mar 24;48(6):1886-900. doi: 10.1021/jm040099a. J Med Chem. 2005. PMID: 15771433

5

3-Acyl-2,6-diaminopyridines as cyclin-dependent kinase inhibitors: synthesis and biological evaluation.

Lin R, Lu Y, Wetter SK, Connolly PJ, Turchi IJ, Murray WV, Emanuel SL, Gruninger RH, Fuentes-Pesquera AR, Adams M, Pandey N, Moreno-Mazza S, Middleton SA, Jolliffe LK. Lin R, et al. Among authors: middleton sa. Bioorg Med Chem Lett. 2005 May 2;15(9):2221-4. doi: 10.1016/j.bmcl.2005.03.024. Bioorg Med Chem Lett. 2005. PMID: 15837297

6

1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities.

Lin R, Connolly PJ, Huang S, Wetter SK, Lu Y, Murray WV, Emanuel SL, Gruninger RH, Fuentes-Pesquera AR, Rugg CA, Middleton SA, Jolliffe LK. Lin R, et al. Among authors: middleton sa. J Med Chem. 2005 Jun 30;48(13):4208-11. doi: 10.1021/jm050267e. J Med Chem. 2005. PMID: 15974571

7

Synthesis and identification of [1,3,5]triazine-pyridine biheteroaryl as a novel series of potent cyclin-dependent kinase inhibitors.

Kuo GH, Deangelis A, Emanuel S, Wang A, Zhang Y, Connolly PJ, Chen X, Gruninger RH, Rugg C, Fuentes-Pesquera A, Middleton SA, Jolliffe L, Murray WV. Kuo GH, et al. Among authors: middleton sa. J Med Chem. 2005 Jul 14;48(14):4535-46. doi: 10.1021/jm040214h. J Med Chem. 2005. PMID: 15999992

8

Synthesis and structure-activity relationships of pyrazine-pyridine biheteroaryls as novel, potent, and selective vascular endothelial growth factor receptor-2 inhibitors.

Kuo GH, Prouty C, Wang A, Emanuel S, Deangelis A, Zhang Y, Song F, Beall L, Connolly PJ, Karnachi P, Chen X, Gruninger RH, Sechler J, Fuentes-Pesquera A, Middleton SA, Jolliffe L, Murray WV. Kuo GH, et al. Among authors: middleton sa. J Med Chem. 2005 Jul 28;48(15):4892-909. doi: 10.1021/jm058205b. J Med Chem. 2005. PMID: 16033269

9

Synthesis of 2-amino-4-(7-azaindol-3-yl)pyrimidines as cyclin dependent kinase 1 (CDK1) inhibitors.

Huang S, Li R, Connolly PJ, Emanuel S, Middleton SA. Huang S, et al. Among authors: middleton sa. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4818-21. doi: 10.1016/j.bmcl.2006.06.073. Epub 2006 Jul 25. Bioorg Med Chem Lett. 2006. PMID: 16870444

10

Synthesis of 3-(1H-benzimidazol-2-yl)-5-isoquinolin-4-ylpyrazolo[1,2-b]pyridine, a potent cyclin dependent kinase 1 (CDK1) inhibitor.

Huang S, Lin R, Yu Y, Lu Y, Connolly PJ, Chiu G, Li S, Emanuel SL, Middleton SA. Huang S, et al. Among authors: middleton sa. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1243-5. doi: 10.1016/j.bmcl.2006.12.031. Epub 2006 Dec 15. Bioorg Med Chem Lett. 2007. PMID: 17234412

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