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Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine.
O'Neill PM, Shone AE, Stanford D, Nixon G, Asadollahy E, Park BK, Maggs JL, Roberts P, Stocks PA, Biagini G, Bray PG, Davies J, Berry N, Hall C, Rimmer K, Winstanley PA, Hindley S, Bambal RB, Davis CB, Bates M, Gresham SL, Brigandi RA, Gomez-de-Las-Heras FM, Gargallo DV, Parapini S, Vivas L, Lander H, Taramelli D, Ward SA. O'Neill PM, et al. Among authors: brigandi ra. J Med Chem. 2009 Apr 9;52(7):1828-44. doi: 10.1021/jm8012757. J Med Chem. 2009. PMID: 19284751 Free article.
Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century.
O'Neill PM, Park BK, Shone AE, Maggs JL, Roberts P, Stocks PA, Biagini GA, Bray PG, Gibbons P, Berry N, Winstanley PA, Mukhtar A, Bonar-Law R, Hindley S, Bambal RB, Davis CB, Bates M, Hart TK, Gresham SL, Lawrence RM, Brigandi RA, Gomez-delas-Heras FM, Gargallo DV, Ward SA. O'Neill PM, et al. Among authors: brigandi ra. J Med Chem. 2009 Mar 12;52(5):1408-15. doi: 10.1021/jm8012618. J Med Chem. 2009. PMID: 19222165
A Novel Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor (GSK1278863) for Anemia in CKD: A 28-Day, Phase 2A Randomized Trial.
Brigandi RA, Johnson B, Oei C, Westerman M, Olbina G, de Zoysa J, Roger SD, Sahay M, Cross N, McMahon L, Guptha V, Smolyarchuk EA, Singh N, Russ SF, Kumar S; PHI112844 Investigators. Brigandi RA, et al. Am J Kidney Dis. 2016 Jun;67(6):861-71. doi: 10.1053/j.ajkd.2015.11.021. Epub 2016 Jan 27. Am J Kidney Dis. 2016. PMID: 26827289 Free article. Clinical Trial.
Emerging therapeutic targets in psoriasis.
Bayliffe AI, Brigandi RA, Wilkins HJ, Levick MP. Bayliffe AI, et al. Among authors: brigandi ra. Curr Opin Pharmacol. 2004 Jun;4(3):306-10. doi: 10.1016/j.coph.2004.02.003. Curr Opin Pharmacol. 2004. PMID: 15140425 Review.
18 results