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A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity.
Bramsen JB, Laursen MB, Nielsen AF, Hansen TB, Bus C, Langkjaer N, Babu BR, Højland T, Abramov M, Van Aerschot A, Odadzic D, Smicius R, Haas J, Andree C, Barman J, Wenska M, Srivastava P, Zhou C, Honcharenko D, Hess S, Müller E, Bobkov GV, Mikhailov SN, Fava E, Meyer TF, Chattopadhyaya J, Zerial M, Engels JW, Herdewijn P, Wengel J, Kjems J. Bramsen JB, et al. Among authors: herdewijn p. Nucleic Acids Res. 2009 May;37(9):2867-81. doi: 10.1093/nar/gkp106. Epub 2009 Mar 12. Nucleic Acids Res. 2009. PMID: 19282453 Free PMC article.
Synthesis of oligonucleotides modified in the sugar moiety.
Augustyns K, Vandendriessche F, Van Aerschot A, Herdewijn P. Augustyns K, et al. Among authors: herdewijn p. Nucleic Acids Symp Ser. 1991;(24):224. Nucleic Acids Symp Ser. 1991. PMID: 1841295 No abstract available.
An acyclic 5-nitroindazole nucleoside analogue as ambiguous nucleoside.
Van Aerschot A, Rozenski J, Loakes D, Pillet N, Schepers G, Herdewijn P. Van Aerschot A, et al. Among authors: herdewijn p. Nucleic Acids Res. 1995 Nov 11;23(21):4363-70. doi: 10.1093/nar/23.21.4363. Nucleic Acids Res. 1995. PMID: 7501457 Free PMC article.
Synthesis and hybridization properties of inverse oligonucleotides.
Marangoni M, Van Aerschot A, Augustyns P, Rozenski J, Herdewijn P. Marangoni M, et al. Among authors: herdewijn p. Nucleic Acids Res. 1997 Aug 1;25(15):3034-41. doi: 10.1093/nar/25.15.3034. Nucleic Acids Res. 1997. PMID: 9224602 Free PMC article.
511 results