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A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity.
Bramsen JB, Laursen MB, Nielsen AF, Hansen TB, Bus C, Langkjaer N, Babu BR, Højland T, Abramov M, Van Aerschot A, Odadzic D, Smicius R, Haas J, Andree C, Barman J, Wenska M, Srivastava P, Zhou C, Honcharenko D, Hess S, Müller E, Bobkov GV, Mikhailov SN, Fava E, Meyer TF, Chattopadhyaya J, Zerial M, Engels JW, Herdewijn P, Wengel J, Kjems J. Bramsen JB, et al. Among authors: chattopadhyaya j. Nucleic Acids Res. 2009 May;37(9):2867-81. doi: 10.1093/nar/gkp106. Epub 2009 Mar 12. Nucleic Acids Res. 2009. PMID: 19282453 Free PMC article.
A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects.
Bramsen JB, Pakula MM, Hansen TB, Bus C, Langkjær N, Odadzic D, Smicius R, Wengel SL, Chattopadhyaya J, Engels JW, Herdewijn P, Wengel J, Kjems J. Bramsen JB, et al. Among authors: chattopadhyaya j. Nucleic Acids Res. 2010 Sep;38(17):5761-73. doi: 10.1093/nar/gkq341. Epub 2010 May 7. Nucleic Acids Res. 2010. PMID: 20453030 Free PMC article.
The synthesis of therapeutic locked nucleos(t)ides.
Zhou C, Chattopadhyaya J. Zhou C, et al. Among authors: chattopadhyaya j. Curr Opin Drug Discov Devel. 2009 Nov;12(6):876-98. Curr Opin Drug Discov Devel. 2009. PMID: 19894196 Review.
132 results