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GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon.
Thangaraju M, Cresci GA, Liu K, Ananth S, Gnanaprakasam JP, Browning DD, Mellinger JD, Smith SB, Digby GJ, Lambert NA, Prasad PD, Ganapathy V. Thangaraju M, et al. Among authors: lambert na. Cancer Res. 2009 Apr 1;69(7):2826-32. doi: 10.1158/0008-5472.CAN-08-4466. Epub 2009 Mar 10. Cancer Res. 2009. PMID: 19276343 Free PMC article.
Some G protein heterotrimers physically dissociate in living cells.
Digby GJ, Lober RM, Sethi PR, Lambert NA. Digby GJ, et al. Among authors: lambert na. Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17789-94. doi: 10.1073/pnas.0607116103. Epub 2006 Nov 9. Proc Natl Acad Sci U S A. 2006. PMID: 17095603 Free PMC article.
Differential dissociation of G protein heterotrimers.
Digby GJ, Sethi PR, Lambert NA. Digby GJ, et al. Among authors: lambert na. J Physiol. 2008 Jul 15;586(14):3325-35. doi: 10.1113/jphysiol.2008.153965. Epub 2008 May 22. J Physiol. 2008. PMID: 18499725 Free PMC article.
A point mutation to Galphai selectively blocks GoLoco motif binding: direct evidence for Galpha.GoLoco complexes in mitotic spindle dynamics.
Willard FS, Zheng Z, Guo J, Digby GJ, Kimple AJ, Conley JM, Johnston CA, Bosch D, Willard MD, Watts VJ, Lambert NA, Ikeda SR, Du Q, Siderovski DP. Willard FS, et al. Among authors: lambert na. J Biol Chem. 2008 Dec 26;283(52):36698-710. doi: 10.1074/jbc.M804936200. Epub 2008 Nov 4. J Biol Chem. 2008. PMID: 18984596 Free PMC article.
111 results