Lewis JW - Search Results

1

Mixed kappa/mu opioid receptor agonists: the 6 beta-naltrexamines.

Cami-Kobeci G, Neal AP, Bradbury FA, Purington LC, Aceto MD, Harris LS, Lewis JW, Traynor JR, Husbands SM. Cami-Kobeci G, et al. Among authors: lewis jw. J Med Chem. 2009 Mar 26;52(6):1546-52. doi: 10.1021/jm8015552. J Med Chem. 2009. PMID: 19253970 Free PMC article.

2

The role of the side chain in determining relative delta- and kappa-affinity in C5'-substituted analogues of naltrindole.

Black SL, Jales AR, Brandt W, Lewis JW, Husbands SM. Black SL, et al. Among authors: lewis jw. J Med Chem. 2003 Jan 16;46(2):314-7. doi: 10.1021/jm020997b. J Med Chem. 2003. PMID: 12519069

3

Opioid ligands having delayed long-term antagonist activity: potential pharmacotherapies for opioid abuse.

Husbands SM, Lewis JW. Husbands SM, et al. Among authors: lewis jw. Mini Rev Med Chem. 2003 Mar;3(2):137-44. doi: 10.2174/1389557033405395. Mini Rev Med Chem. 2003. PMID: 12570846 Review.

4

14-amino, 14-alkylamino, and 14-acylamino analogs of oxymorphindole. Differential effects on opioid receptor binding and functional profiles.

Grundt P, Jales AR, Traynor JR, Lewis JW, Husbands SM. Grundt P, et al. Among authors: lewis jw. J Med Chem. 2003 Apr 10;46(8):1563-6. doi: 10.1021/jm021073r. J Med Chem. 2003. PMID: 12672258

5

Opioid binding and in vitro profiles of a series of 4-hdroxy-3-methoxyindolomorphinans. Transformation of a delta-selective ligand into a high affinity kappa-selective ligand by introduction of a 5,14-substituted bridge.

Grundt P, Martinez-Bermejo F, Lewis JW, Husbands SM. Grundt P, et al. Among authors: lewis jw. J Med Chem. 2003 Jul 3;46(14):3174-7. doi: 10.1021/jm030801n. J Med Chem. 2003. PMID: 12825957

6

Guanidino N-substituted and N,N-disubstituted derivatives of the kappa-opioid antagonist GNTI.

Black SL, Chauvignac C, Grundt P, Miller CN, Wood S, Traynor JR, Lewis JW, Husbands SM. Black SL, et al. Among authors: lewis jw. J Med Chem. 2003 Dec 4;46(25):5505-11. doi: 10.1021/jm0309203. J Med Chem. 2003. PMID: 14640558

7

Identification of a new scaffold for opioid receptor antagonism based on the 2-amino-1,1-dimethyl-7-hydroxytetralin pharmacophore.

Grundt P, Williams IA, Lewis JW, Husbands SM. Grundt P, et al. Among authors: lewis jw. J Med Chem. 2004 Oct 7;47(21):5069-75. doi: 10.1021/jm040807s. J Med Chem. 2004. PMID: 15456250

8

Effects of substitution on the pyrrole N atom in derivatives of tetrahydronaltrindole, tetrahydrooxymorphindole, and a related 4,5-epoxyphenylpyrrolomorphinan.

Srivastava SK, Shefali S, Miller CN, Aceto MD, Traynor JR, Lewis JW, Husbands SM. Srivastava SK, et al. Among authors: lewis jw. J Med Chem. 2004 Dec 16;47(26):6645-8. doi: 10.1021/jm040817t. J Med Chem. 2004. PMID: 15588100

9

Extension of the Nenitzescu reaction to simple ketones provides an efficient route to 1'-alkyl-5'-hydroxynaltrindole analogues, potent and selective delta-opioid receptor antagonists.

Shefali S, Srivastava SK, Husbands SM, Lewis JW. Shefali S, et al. Among authors: lewis jw. J Med Chem. 2005 Jan 27;48(2):635-8. doi: 10.1021/jm040853s. J Med Chem. 2005. PMID: 15658877

10

BU74, a complex oripavine derivative with potent kappa opioid receptor agonism and delayed opioid antagonism.

Husbands SM, Neilan CL, Broadbear J, Grundt P, Breeden S, Aceto MD, Woods JH, Lewis JW, Traynor JR. Husbands SM, et al. Among authors: lewis jw. Eur J Pharmacol. 2005 Feb 21;509(2-3):117-25. doi: 10.1016/j.ejphar.2004.12.035. Eur J Pharmacol. 2005. PMID: 15733546

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