Anderson AC - Search Results

1

Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance.

Frey KM, Liu J, Lombardo MN, Bolstad DB, Wright DL, Anderson AC. Frey KM, et al. Among authors: anderson ac. J Mol Biol. 2009 Apr 17;387(5):1298-308. doi: 10.1016/j.jmb.2009.02.045. Epub 2009 Feb 26. J Mol Biol. 2009. PMID: 19249312 Free PMC article.

2

Structure-guided development of efficacious antifungal agents targeting Candida glabrata dihydrofolate reductase.

Liu J, Bolstad DB, Smith AE, Priestley ND, Wright DL, Anderson AC. Liu J, et al. Among authors: anderson ac. Chem Biol. 2008 Sep 22;15(9):990-6. doi: 10.1016/j.chembiol.2008.07.013. Chem Biol. 2008. PMID: 18804036 Free PMC article.

3

Structure-based approach to the development of potent and selective inhibitors of dihydrofolate reductase from cryptosporidium.

Bolstad DB, Bolstad ES, Frey KM, Wright DL, Anderson AC. Bolstad DB, et al. Among authors: anderson ac. J Med Chem. 2008 Nov 13;51(21):6839-52. doi: 10.1021/jm8009124. Epub 2008 Oct 4. J Med Chem. 2008. PMID: 18834108 Free PMC article.

4

Synthetic and crystallographic studies of a new inhibitor series targeting Bacillus anthracis dihydrofolate reductase.

Beierlein JM, Frey KM, Bolstad DB, Pelphrey PM, Joska TM, Smith AE, Priestley ND, Wright DL, Anderson AC. Beierlein JM, et al. Among authors: anderson ac. J Med Chem. 2008 Dec 11;51(23):7532-40. doi: 10.1021/jm800776a. J Med Chem. 2008. PMID: 19007108 Free PMC article.

5

Probing the active site of Candida glabrata dihydrofolate reductase with high resolution crystal structures and the synthesis of new inhibitors.

Liu J, Bolstad DB, Smith AE, Priestley ND, Wright DL, Anderson AC. Liu J, et al. Among authors: anderson ac. Chem Biol Drug Des. 2009 Jan;73(1):62-74. doi: 10.1111/j.1747-0285.2008.00745.x. Chem Biol Drug Des. 2009. PMID: 19152636 Free PMC article.

6

Towards new antifolates targeting eukaryotic opportunistic infections.

Liu J, Bolstad DB, Bolstad ES, Wright DL, Anderson AC. Liu J, et al. Among authors: anderson ac. Eukaryot Cell. 2009 Apr;8(4):483-6. doi: 10.1128/EC.00298-08. Epub 2009 Jan 23. Eukaryot Cell. 2009. PMID: 19168759 Free PMC article.

7

The solution structure of Bacillus anthracis dihydrofolate reductase yields insight into the analysis of structure-activity relationships for novel inhibitors.

Beierlein JM, Deshmukh L, Frey KM, Vinogradova O, Anderson AC. Beierlein JM, et al. Among authors: anderson ac. Biochemistry. 2009 May 19;48(19):4100-8. doi: 10.1021/bi802319w. Biochemistry. 2009. PMID: 19323450 Free PMC article.

8

In vitro biological activity and structural analysis of 2,4-diamino-5-(2'-arylpropargyl)pyrimidine inhibitors of Candida albicans.

Paulsen JL, Liu J, Bolstad DB, Smith AE, Priestley ND, Wright DL, Anderson AC. Paulsen JL, et al. Among authors: anderson ac. Bioorg Med Chem. 2009 Jul 15;17(14):4866-72. doi: 10.1016/j.bmc.2009.06.021. Epub 2009 Jun 17. Bioorg Med Chem. 2009. PMID: 19560363 Free PMC article.

9

Towards the understanding of resistance mechanisms in clinically isolated trimethoprim-resistant, methicillin-resistant Staphylococcus aureus dihydrofolate reductase.

Frey KM, Lombardo MN, Wright DL, Anderson AC. Frey KM, et al. Among authors: anderson ac. J Struct Biol. 2010 Apr;170(1):93-7. doi: 10.1016/j.jsb.2009.12.011. Epub 2009 Dec 21. J Struct Biol. 2010. PMID: 20026215 Free PMC article.

10

Predicting resistance mutations using protein design algorithms.

Frey KM, Georgiev I, Donald BR, Anderson AC. Frey KM, et al. Among authors: anderson ac. Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13707-12. doi: 10.1073/pnas.1002162107. Epub 2010 Jul 19. Proc Natl Acad Sci U S A. 2010. PMID: 20643959 Free PMC article.

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