Schüler H - Search Results

1

The DEXD/H-box RNA helicase DDX19 is regulated by an {alpha}-helical switch.

Collins R, Karlberg T, Lehtiö L, Schütz P, van den Berg S, Dahlgren LG, Hammarström M, Weigelt J, Schüler H. Collins R, et al. Among authors: schuler h. J Biol Chem. 2009 Apr 17;284(16):10296-300. doi: 10.1074/jbc.C900018200. Epub 2009 Feb 25. J Biol Chem. 2009. PMID: 19244245 Free PMC article.

2

Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy.

Kursula P, Flodin S, Ehn M, Hammarström M, Schüler H, Nordlund P, Stenmark P. Kursula P, et al. Among authors: schuler h. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jul 1;62(Pt 7):613-7. doi: 10.1107/S1744309106018136. Epub 2006 Jun 10. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006. PMID: 16820675 Free PMC article.

3

Structures of the hydrolase domain of human 10-formyltetrahydrofolate dehydrogenase and its complex with a substrate analogue.

Kursula P, Schüler H, Flodin S, Nilsson-Ehle P, Ogg DJ, Savitsky P, Nordlund P, Stenmark P. Kursula P, et al. Among authors: schuler h. Acta Crystallogr D Biol Crystallogr. 2006 Nov;62(Pt 11):1294-9. doi: 10.1107/S0907444906026849. Epub 2006 Oct 18. Acta Crystallogr D Biol Crystallogr. 2006. PMID: 17057331

4

Crystal structure of human inosine triphosphatase. Substrate binding and implication of the inosine triphosphatase deficiency mutation P32T.

Stenmark P, Kursula P, Flodin S, Gräslund S, Landry R, Nordlund P, Schüler H. Stenmark P, et al. Among authors: schuler h. J Biol Chem. 2007 Feb 2;282(5):3182-7. doi: 10.1074/jbc.M609838200. Epub 2006 Nov 29. J Biol Chem. 2007. PMID: 17138556 Free article.

5

The crystal structure of human cleavage and polyadenylation specific factor-5 reveals a dimeric Nudix protein with a conserved catalytic site.

Trésaugues L, Stenmark P, Schüler H, Flodin S, Welin M, Nyman T, Hammarström M, Moche M, Gräslund S, Nordlund P. Trésaugues L, et al. Among authors: schuler h. Proteins. 2008 Dec;73(4):1047-52. doi: 10.1002/prot.22198. Proteins. 2008. PMID: 18767156 No abstract available.

6

Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3.

Lehtiö L, Jemth AS, Collins R, Loseva O, Johansson A, Markova N, Hammarström M, Flores A, Holmberg-Schiavone L, Weigelt J, Helleday T, Schüler H, Karlberg T. Lehtiö L, et al. Among authors: schuler h. J Med Chem. 2009 May 14;52(9):3108-11. doi: 10.1021/jm900052j. J Med Chem. 2009. PMID: 19354255

7

Crystal structure of the ATPase domain of the human AAA+ protein paraplegin/SPG7.

Karlberg T, van den Berg S, Hammarström M, Sagemark J, Johansson I, Holmberg-Schiavone L, Schüler H. Karlberg T, et al. Among authors: schuler h. PLoS One. 2009 Oct 20;4(10):e6975. doi: 10.1371/journal.pone.0006975. PLoS One. 2009. PMID: 19841671 Free PMC article.

8

PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA.

Loseva O, Jemth AS, Bryant HE, Schüler H, Lehtiö L, Karlberg T, Helleday T. Loseva O, et al. Among authors: schuler h. J Biol Chem. 2010 Mar 12;285(11):8054-60. doi: 10.1074/jbc.M109.077834. Epub 2010 Jan 11. J Biol Chem. 2010. PMID: 20064938 Free PMC article.

9

Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78.

Wisniewska M, Karlberg T, Lehtiö L, Johansson I, Kotenyova T, Moche M, Schüler H. Wisniewska M, et al. Among authors: schuler h. PLoS One. 2010 Jan 11;5(1):e8625. doi: 10.1371/journal.pone.0008625. PLoS One. 2010. PMID: 20072699 Free PMC article.

10

Crystal structure of the catalytic domain of human PARP2 in complex with PARP inhibitor ABT-888.

Karlberg T, Hammarström M, Schütz P, Svensson L, Schüler H. Karlberg T, et al. Among authors: schuler h. Biochemistry. 2010 Feb 16;49(6):1056-8. doi: 10.1021/bi902079y. Biochemistry. 2010. PMID: 20092359

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