Igarashi J - Search Results

1

Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy.

Ji H, Tan S, Igarashi J, Li H, Derrick M, Martásek P, Roman LJ, Vásquez-Vivar J, Poulos TL, Silverman RB. Ji H, et al. Among authors: igarashi j. Ann Neurol. 2009 Feb;65(2):209-17. doi: 10.1002/ana.21555. Ann Neurol. 2009. PMID: 19235180 Free PMC article.

2

Minimal pharmacophoric elements and fragment hopping, an approach directed at molecular diversity and isozyme selectivity. Design of selective neuronal nitric oxide synthase inhibitors.

Ji H, Stanton BZ, Igarashi J, Li H, Martásek P, Roman LJ, Poulos TL, Silverman RB. Ji H, et al. Among authors: igarashi j. J Am Chem Soc. 2008 Mar 26;130(12):3900-14. doi: 10.1021/ja0772041. Epub 2008 Mar 6. J Am Chem Soc. 2008. PMID: 18321097 Free PMC article.

3

Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors.

Igarashi J, Li H, Jamal J, Ji H, Fang J, Lawton GR, Silverman RB, Poulos TL. Igarashi J, et al. J Med Chem. 2009 Apr 9;52(7):2060-6. doi: 10.1021/jm900007a. J Med Chem. 2009. PMID: 19296678 Free PMC article.

4

Exploring the binding conformations of bulkier dipeptide amide inhibitors in constitutive nitric oxide synthases.

Li H, Flinspach ML, Igarashi J, Jamal J, Yang W, Gómez-Vidal JA, Litzinger EA, Huang H, Erdal EP, Silverman RB, Poulos TL. Li H, et al. Among authors: igarashi j. Biochemistry. 2005 Nov 22;44(46):15222-9. doi: 10.1021/bi0513610. Biochemistry. 2005. PMID: 16285725

5

Structural studies of constitutive nitric oxide synthases with diatomic ligands bound.

Li H, Igarashi J, Jamal J, Yang W, Poulos TL. Li H, et al. Among authors: igarashi j. J Biol Inorg Chem. 2006 Sep;11(6):753-68. doi: 10.1007/s00775-006-0123-8. Epub 2006 Jun 28. J Biol Inorg Chem. 2006. PMID: 16804678

6

Analysis of the kinetics of CO binding to neuronal nitric oxide synthase by flash photolysis: dual effects of substrates, inhibitors, and tetrahydrobiopterin.

Bengea S, Araki Y, Ito O, Igarashi J, Sagami I, Shimizu T. Bengea S, et al. Among authors: igarashi j. J Inorg Biochem. 2004 Jul;98(7):1210-6. doi: 10.1016/j.jinorgbio.2004.04.009. J Inorg Biochem. 2004. PMID: 15219987

7

CO binding study of mouse heme-regulated eIF-2alpha kinase: kinetics and resonance Raman spectra.

Igarashi J, Sato A, Kitagawa T, Sagami I, Shimizu T. Igarashi J, et al. Biochim Biophys Acta. 2003 Aug 21;1650(1-2):99-104. doi: 10.1016/s1570-9639(03)00205-x. Biochim Biophys Acta. 2003. PMID: 12922173

8

Binding of oxygen and carbon monoxide to a heme-regulated phosphodiesterase from Escherichia coli. Kinetics and infrared spectra of the full-length wild-type enzyme, isolated PAS domain, and Met-95 mutants.

Taguchi S, Matsui T, Igarashi J, Sasakura Y, Araki Y, Ito O, Sugiyama S, Sagami I, Shimizu T. Taguchi S, et al. Among authors: igarashi j. J Biol Chem. 2004 Jan 30;279(5):3340-7. doi: 10.1074/jbc.M301013200. Epub 2003 Nov 11. J Biol Chem. 2004. PMID: 14612459 Free article.

9

SOUL in mouse eyes is a new hexameric heme-binding protein with characteristic optical absorption, resonance Raman spectral, and heme-binding properties.

Sato E, Sagami I, Uchida T, Sato A, Kitagawa T, Igarashi J, Shimizu T. Sato E, et al. Among authors: igarashi j. Biochemistry. 2004 Nov 9;43(44):14189-98. doi: 10.1021/bi048742i. Biochemistry. 2004. PMID: 15518569

10

Critical roles of Leu99 and Leu115 at the heme distal side in auto-oxidation and the redox potential of a heme-regulated phosphodiesterase from Escherichia coli.

Yokota N, Araki Y, Kurokawa H, Ito O, Igarashi J, Shimizu T. Yokota N, et al. Among authors: igarashi j. FEBS J. 2006 Mar;273(6):1210-23. doi: 10.1111/j.1742-4658.2006.05145.x. FEBS J. 2006. PMID: 16519686 Free article.

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