Chiang PC - Search Results

1

Pharmacokinetic and pharmacodynamic evaluation of the suitability of using fluticasone and an acute rat lung inflammation model to differentiate lung versus systemic efficacy.

Chiang PC, Hu Y, Thurston A, Sommers CD, Guzova JA, Kahn LE, Lai Y, Blom JD. Chiang PC, et al. J Pharm Sci. 2009 Nov;98(11):4354-64. doi: 10.1002/jps.21714. J Pharm Sci. 2009. PMID: 19230021

2

Fluticasone and budesonide nanosuspensions for pulmonary delivery: preparation, characterization, and pharmacokinetic studies.

Yang JZ, Young AL, Chiang PC, Thurston A, Pretzer DK. Yang JZ, et al. Among authors: chiang pc. J Pharm Sci. 2008 Nov;97(11):4869-78. doi: 10.1002/jps.21380. J Pharm Sci. 2008. PMID: 18351635

3

Aqueous versus non-aqueous salt delivery strategies to enhance oral bioavailability of a mitogen-activated protein kinase-activated protein kinase (MK-2) inhibitor in rats.

Chiang PC, South SA, Daniels JS, Anderson DR, Wene SP, Albin LA, Mourey RJ, Selbo JG. Chiang PC, et al. J Pharm Sci. 2009 Jan;98(1):248-56. doi: 10.1002/jps.21425. J Pharm Sci. 2009. PMID: 18449936

4

A novel, highly selective, tight binding IkappaB kinase-2 (IKK-2) inhibitor: a tool to correlate IKK-2 activity to the fate and functions of the components of the nuclear factor-kappaB pathway in arthritis-relevant cells and animal models.

Mbalaviele G, Sommers CD, Bonar SL, Mathialagan S, Schindler JF, Guzova JA, Shaffer AF, Melton MA, Christine LJ, Tripp CS, Chiang PC, Thompson DC, Hu Y, Kishore N. Mbalaviele G, et al. Among authors: chiang pc. J Pharmacol Exp Ther. 2009 Apr;329(1):14-25. doi: 10.1124/jpet.108.143800. Epub 2009 Jan 23. J Pharmacol Exp Ther. 2009. PMID: 19168710

5

Simultaneous determination of LogD, LogP, and pK(a) of drugs by using a reverse phase HPLC coupled with a 96-well plate auto injector.

Chiang PC, Hu Y. Chiang PC, et al. Comb Chem High Throughput Screen. 2009 Mar;12(3):250-7. doi: 10.2174/138620709787581693. Comb Chem High Throughput Screen. 2009. PMID: 19275530

6

Novel tight-binding inhibitory factor-kappaB kinase (IKK-2) inhibitors demonstrate target-specific anti-inflammatory activities in cellular assays and following oral and local delivery in an in vivo model of airway inflammation.

Sommers CD, Thompson JM, Guzova JA, Bonar SL, Rader RK, Mathialagan S, Venkatraman N, Holway VW, Kahn LE, Hu G, Garner DS, Huang HC, Chiang PC, Schindler JF, Hu Y, Meyer DM, Kishore NN. Sommers CD, et al. Among authors: chiang pc. J Pharmacol Exp Ther. 2009 Aug;330(2):377-88. doi: 10.1124/jpet.108.147538. Epub 2009 May 28. J Pharmacol Exp Ther. 2009. PMID: 19478133

7

Combined use of pharmacokinetic modeling and a steady-state delivery approach allows early assessment of IkappaB kinase-2 (IKK-2) target safety and efficacy.

Chiang PC, Kishore NN, Thompson DC. Chiang PC, et al. J Pharm Sci. 2010 Mar;99(3):1278-87. doi: 10.1002/jps.21909. J Pharm Sci. 2010. PMID: 19743500

8

Euthanasia method for mice in rapid time-course pulmonary pharmacokinetic studies.

Schoell AR, Heyde BR, Weir DE, Chiang PC, Hu Y, Tung DK. Schoell AR, et al. Among authors: chiang pc. J Am Assoc Lab Anim Sci. 2009 Sep;48(5):506-11. J Am Assoc Lab Anim Sci. 2009. PMID: 19807971 Free PMC article.

9

Utilizing a novel tandem oral dosing strategy to enhance exposure of low-solubility drug candidates in a preclinical setting.

Chiang PC, South SA, Foster KA, Daniels JS, Wene SP, Albin LA, Thompson DC. Chiang PC, et al. J Pharm Sci. 2010 Jul;99(7):3132-40. doi: 10.1002/jps.22092. J Pharm Sci. 2010. PMID: 20229600

10

Evaluation of Aerosol Delivery of Nanosuspension for Pre-clinical Pulmonary Drug Delivery.

Chiang PC, Alsup JW, Lai Y, Hu Y, Heyde BR, Tung D. Chiang PC, et al. Nanoscale Res Lett. 2009 Jan 6;4(3):254-261. doi: 10.1007/s11671-008-9234-1. Nanoscale Res Lett. 2009. PMID: 20596335 Free PMC article.

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