Metzler M - Search Results

1

Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease.

Graham RK, Pouladi MA, Joshi P, Lu G, Deng Y, Wu NP, Figueroa BE, Metzler M, André VM, Slow EJ, Raymond L, Friedlander R, Levine MS, Leavitt BR, Hayden MR. Graham RK, et al. Among authors: metzler m. J Neurosci. 2009 Feb 18;29(7):2193-204. doi: 10.1523/JNEUROSCI.5473-08.2009. J Neurosci. 2009. PMID: 19228972 Free PMC article.

2

Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain.

Van Raamsdonk JM, Metzler M, Slow E, Pearson J, Schwab C, Carroll J, Graham RK, Leavitt BR, Hayden MR. Van Raamsdonk JM, et al. Among authors: metzler m. Neurobiol Dis. 2007 Apr;26(1):189-200. doi: 10.1016/j.nbd.2006.12.010. Epub 2006 Dec 29. Neurobiol Dis. 2007. PMID: 17276692

3

Phosphorylation of huntingtin at Ser421 in YAC128 neurons is associated with protection of YAC128 neurons from NMDA-mediated excitotoxicity and is modulated by PP1 and PP2A.

Metzler M, Gan L, Mazarei G, Graham RK, Liu L, Bissada N, Lu G, Leavitt BR, Hayden MR. Metzler M, et al. J Neurosci. 2010 Oct 27;30(43):14318-29. doi: 10.1523/JNEUROSCI.1589-10.2010. J Neurosci. 2010. PMID: 20980587 Free PMC article.

4

Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo.

Graham RK, Deng Y, Carroll J, Vaid K, Cowan C, Pouladi MA, Metzler M, Bissada N, Wang L, Faull RL, Gray M, Yang XW, Raymond LA, Hayden MR. Graham RK, et al. Among authors: metzler m. J Neurosci. 2010 Nov 10;30(45):15019-29. doi: 10.1523/JNEUROSCI.2071-10.2010. J Neurosci. 2010. PMID: 21068307 Free PMC article.

5

NMDA receptor function and NMDA receptor-dependent phosphorylation of huntingtin is altered by the endocytic protein HIP1.

Metzler M, Gan L, Wong TP, Liu L, Helm J, Liu L, Georgiou J, Wang Y, Bissada N, Cheng K, Roder JC, Wang YT, Hayden MR. Metzler M, et al. J Neurosci. 2007 Feb 28;27(9):2298-308. doi: 10.1523/JNEUROSCI.5175-06.2007. J Neurosci. 2007. PMID: 17329427 Free PMC article.

6

Absence of disease phenotype and intergenerational stability of the CAG repeat in transgenic mice expressing the human Huntington disease transcript.

Goldberg YP, Kalchman MA, Metzler M, Nasir J, Zeisler J, Graham R, Koide HB, O'Kusky J, Sharp AH, Ross CA, Jirik F, Hayden MR. Goldberg YP, et al. Among authors: metzler m. Hum Mol Genet. 1996 Feb;5(2):177-85. doi: 10.1093/hmg/5.2.177. Hum Mol Genet. 1996. PMID: 8824873

7

Life without huntingtin: normal differentiation into functional neurons.

Metzler M, Chen N, Helgason CD, Graham RK, Nichol K, McCutcheon K, Nasir J, Humphries RK, Raymond LA, Hayden MR. Metzler M, et al. J Neurochem. 1999 Mar;72(3):1009-18. doi: 10.1046/j.1471-4159.1999.0721009.x. J Neurochem. 1999. PMID: 10037472 Free article.

8

HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis.

Singaraja RR, Hadano S, Metzler M, Givan S, Wellington CL, Warby S, Yanai A, Gutekunst CA, Leavitt BR, Yi H, Fichter K, Gan L, McCutcheon K, Chopra V, Michel J, Hersch SM, Ikeda JE, Hayden MR. Singaraja RR, et al. Among authors: metzler m. Hum Mol Genet. 2002 Nov 1;11(23):2815-28. doi: 10.1093/hmg/11.23.2815. Hum Mol Genet. 2002. PMID: 12393793

9

Huntingtin-interacting protein 1 influences worm and mouse presynaptic function and protects Caenorhabditis elegans neurons against mutant polyglutamine toxicity.

Parker JA, Metzler M, Georgiou J, Mage M, Roder JC, Rose AM, Hayden MR, Néri C. Parker JA, et al. Among authors: metzler m. J Neurosci. 2007 Oct 10;27(41):11056-64. doi: 10.1523/JNEUROSCI.1941-07.2007. J Neurosci. 2007. PMID: 17928447 Free PMC article.

10

Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin.

Chen N, Luo T, Wellington C, Metzler M, McCutcheon K, Hayden MR, Raymond LA. Chen N, et al. Among authors: metzler m. J Neurochem. 1999 May;72(5):1890-8. doi: 10.1046/j.1471-4159.1999.0721890.x. J Neurochem. 1999. PMID: 10217265 Free article.

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