Lu G - Search Results

1

Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease.

Graham RK, Pouladi MA, Joshi P, Lu G, Deng Y, Wu NP, Figueroa BE, Metzler M, André VM, Slow EJ, Raymond L, Friedlander R, Levine MS, Leavitt BR, Hayden MR. Graham RK, et al. Among authors: lu g. J Neurosci. 2009 Feb 18;29(7):2193-204. doi: 10.1523/JNEUROSCI.5473-08.2009. J Neurosci. 2009. PMID: 19228972 Free PMC article.

2

Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions.

Slow EJ, Graham RK, Osmand AP, Devon RS, Lu G, Deng Y, Pearson J, Vaid K, Bissada N, Wetzel R, Leavitt BR, Hayden MR. Slow EJ, et al. Among authors: lu g. Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11402-7. doi: 10.1073/pnas.0503634102. Epub 2005 Aug 2. Proc Natl Acad Sci U S A. 2005. PMID: 16076956 Free PMC article.

3

Ethyl-EPA treatment improves motor dysfunction, but not neurodegeneration in the YAC128 mouse model of Huntington disease.

Van Raamsdonk JM, Pearson J, Rogers DA, Lu G, Barakauskas VE, Barr AM, Honer WG, Hayden MR, Leavitt BR. Van Raamsdonk JM, et al. Among authors: lu g. Exp Neurol. 2005 Dec;196(2):266-72. doi: 10.1016/j.expneurol.2005.07.021. Epub 2005 Aug 29. Exp Neurol. 2005. PMID: 16129433

4

Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models.

Graham RK, Slow EJ, Deng Y, Bissada N, Lu G, Pearson J, Shehadeh J, Leavitt BR, Raymond LA, Hayden MR. Graham RK, et al. Among authors: lu g. Neurobiol Dis. 2006 Feb;21(2):444-55. doi: 10.1016/j.nbd.2005.08.007. Epub 2005 Oct 17. Neurobiol Dis. 2006. PMID: 16230019

5

Body weight is modulated by levels of full-length huntingtin.

Van Raamsdonk JM, Gibson WT, Pearson J, Murphy Z, Lu G, Leavitt BR, Hayden MR. Van Raamsdonk JM, et al. Among authors: lu g. Hum Mol Genet. 2006 May 1;15(9):1513-23. doi: 10.1093/hmg/ddl072. Epub 2006 Mar 28. Hum Mol Genet. 2006. PMID: 16571604

6

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.

Graham RK, Deng Y, Slow EJ, Haigh B, Bissada N, Lu G, Pearson J, Shehadeh J, Bertram L, Murphy Z, Warby SC, Doty CN, Roy S, Wellington CL, Leavitt BR, Raymond LA, Nicholson DW, Hayden MR. Graham RK, et al. Among authors: lu g. Cell. 2006 Jun 16;125(6):1179-91. doi: 10.1016/j.cell.2006.04.026. Cell. 2006. PMID: 16777606 Free article.

7

Progranulin expression in the developing and adult murine brain.

Petkau TL, Neal SJ, Orban PC, MacDonald JL, Hill AM, Lu G, Feldman HH, Mackenzie IR, Leavitt BR. Petkau TL, et al. Among authors: lu g. J Comp Neurol. 2010 Oct 1;518(19):3931-47. doi: 10.1002/cne.22430. J Comp Neurol. 2010. PMID: 20737593

8

Phosphorylation of huntingtin at Ser421 in YAC128 neurons is associated with protection of YAC128 neurons from NMDA-mediated excitotoxicity and is modulated by PP1 and PP2A.

Metzler M, Gan L, Mazarei G, Graham RK, Liu L, Bissada N, Lu G, Leavitt BR, Hayden MR. Metzler M, et al. Among authors: lu g. J Neurosci. 2010 Oct 27;30(43):14318-29. doi: 10.1523/JNEUROSCI.1589-10.2010. J Neurosci. 2010. PMID: 20980587 Free PMC article.

9

Synaptic dysfunction in progranulin-deficient mice.

Petkau TL, Neal SJ, Milnerwood A, Mew A, Hill AM, Orban P, Gregg J, Lu G, Feldman HH, Mackenzie IR, Raymond LA, Leavitt BR. Petkau TL, et al. Among authors: lu g. Neurobiol Dis. 2012 Feb;45(2):711-22. doi: 10.1016/j.nbd.2011.10.016. Epub 2011 Oct 25. Neurobiol Dis. 2012. PMID: 22062772

10

Sensitivity to neurotoxic stress is not increased in progranulin-deficient mice.

Petkau TL, Zhu S, Lu G, Fernando S, Cynader M, Leavitt BR. Petkau TL, et al. Among authors: lu g. Neurobiol Aging. 2013 Nov;34(11):2548-50. doi: 10.1016/j.neurobiolaging.2013.04.019. Epub 2013 May 21. Neurobiol Aging. 2013. PMID: 23702345

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