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A small-molecule dengue virus entry inhibitor.
Wang QY, Patel SJ, Vangrevelinghe E, Xu HY, Rao R, Jaber D, Schul W, Gu F, Heudi O, Ma NL, Poh MK, Phong WY, Keller TH, Jacoby E, Vasudevan SG. Wang QY, et al. Among authors: jacoby e. Antimicrob Agents Chemother. 2009 May;53(5):1823-31. doi: 10.1128/AAC.01148-08. Epub 2009 Feb 17. Antimicrob Agents Chemother. 2009. PMID: 19223625 Free PMC article.
A novel class of oral direct renin inhibitors: highly potent 3,5-disubstituted piperidines bearing a tricyclic p3-p1 pharmacophore.
Ostermann N, Ruedisser S, Ehrhardt C, Breitenstein W, Marzinzik A, Jacoby E, Vangrevelinghe E, Ottl J, Klumpp M, Hartwieg JC, Cumin F, Hassiepen U, Trappe J, Sedrani R, Geisse S, Gerhartz B, Richert P, Francotte E, Wagner T, Krömer M, Kosaka T, Webb RL, Rigel DF, Maibaum J, Baeschlin DK. Ostermann N, et al. Among authors: jacoby e. J Med Chem. 2013 Mar 28;56(6):2196-206. doi: 10.1021/jm301706j. Epub 2013 Mar 15. J Med Chem. 2013. PMID: 23360239
Which aspects of HTS are empirically correlated with downstream success?
Bender A, Bojanic D, Davies JW, Crisman TJ, Mikhailov D, Scheiber J, Jenkins JL, Deng Z, Hill WA, Popov M, Jacoby E, Glick M. Bender A, et al. Among authors: jacoby e. Curr Opin Drug Discov Devel. 2008 May;11(3):327-37. Curr Opin Drug Discov Devel. 2008. PMID: 18428086 Review.
The 7 TM G-protein-coupled receptor target family.
Jacoby E, Bouhelal R, Gerspacher M, Seuwen K. Jacoby E, et al. ChemMedChem. 2006 Aug;1(8):761-82. doi: 10.1002/cmdc.200600134. ChemMedChem. 2006. PMID: 16902930 Review.
223 results