Spannhoff A - Search Results

1

Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294.

Chang Y, Zhang X, Horton JR, Upadhyay AK, Spannhoff A, Liu J, Snyder JP, Bedford MT, Cheng X. Chang Y, et al. Among authors: spannhoff a. Nat Struct Mol Biol. 2009 Mar;16(3):312-7. doi: 10.1038/nsmb.1560. Epub 2009 Feb 15. Nat Struct Mol Biol. 2009. PMID: 19219047 Free PMC article.

2

Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases.

Chang Y, Ganesh T, Horton JR, Spannhoff A, Liu J, Sun A, Zhang X, Bedford MT, Shinkai Y, Snyder JP, Cheng X. Chang Y, et al. Among authors: spannhoff a. J Mol Biol. 2010 Jul 2;400(1):1-7. doi: 10.1016/j.jmb.2010.04.048. Epub 2010 Apr 29. J Mol Biol. 2010. PMID: 20434463 Free PMC article.

3

A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics.

Quinn AM, Bedford MT, Espejo A, Spannhoff A, Austin CP, Oppermann U, Simeonov A. Quinn AM, et al. Among authors: spannhoff a. Nucleic Acids Res. 2010 Jan;38(2):e11. doi: 10.1093/nar/gkp899. Epub 2009 Nov 6. Nucleic Acids Res. 2010. PMID: 19897549 Free PMC article.

4

Design, synthesis and biological evaluation of carboxy analogues of arginine methyltransferase inhibitor 1 (AMI-1).

Castellano S, Milite C, Ragno R, Simeoni S, Mai A, Limongelli V, Novellino E, Bauer I, Brosch G, Spannhoff A, Cheng D, Bedford MT, Sbardella G. Castellano S, et al. Among authors: spannhoff a. ChemMedChem. 2010 Mar 1;5(3):398-414. doi: 10.1002/cmdc.200900459. ChemMedChem. 2010. PMID: 20091730

5

Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1.

Bissinger EM, Heinke R, Spannhoff A, Eberlin A, Metzger E, Cura V, Hassenboehler P, Cavarelli J, Schüle R, Bedford MT, Sippl W, Jung M. Bissinger EM, et al. Among authors: spannhoff a. Bioorg Med Chem. 2011 Jun 15;19(12):3717-31. doi: 10.1016/j.bmc.2011.02.032. Epub 2011 Feb 27. Bioorg Med Chem. 2011. PMID: 21440447

6

Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees.

Spannhoff A, Kim YK, Raynal NJ, Gharibyan V, Su MB, Zhou YY, Li J, Castellano S, Sbardella G, Issa JP, Bedford MT. Spannhoff A, et al. EMBO Rep. 2011 Mar;12(3):238-43. doi: 10.1038/embor.2011.9. Epub 2011 Feb 18. EMBO Rep. 2011. PMID: 21331099 Free PMC article.

7

Identification of small-molecule enhancers of arginine methylation catalyzed by coactivator-associated arginine methyltransferase 1.

Castellano S, Spannhoff A, Milite C, Dal Piaz F, Cheng D, Tosco A, Viviano M, Yamani A, Cianciulli A, Sala M, Cura V, Cavarelli J, Novellino E, Mai A, Bedford MT, Sbardella G. Castellano S, et al. Among authors: spannhoff a. J Med Chem. 2012 Nov 26;55(22):9875-90. doi: 10.1021/jm301097p. Epub 2012 Nov 2. J Med Chem. 2012. PMID: 23095008 Free PMC article.

8

Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms.

Woolard J, Vousden W, Moss SJ, Krishnakumar A, Gammons MV, Nowak DG, Dixon N, Micklefield J, Spannhoff A, Bedford MT, Gregory MA, Martin CJ, Leadlay PF, Zhang MQ, Harper SJ, Bates DO, Wilkinson B. Woolard J, et al. Among authors: spannhoff a. Chem Sci. 2011 Feb 1;2011(2):273-278. doi: 10.1039/C0SC00297F. Chem Sci. 2011. PMID: 22822423 Free PMC article.

9

The emerging therapeutic potential of histone methyltransferase and demethylase inhibitors.

Spannhoff A, Hauser AT, Heinke R, Sippl W, Jung M. Spannhoff A, et al. ChemMedChem. 2009 Oct;4(10):1568-82. doi: 10.1002/cmdc.200900301. ChemMedChem. 2009. PMID: 19739196 Review.

10

A novel arginine methyltransferase inhibitor with cellular activity.

Spannhoff A, Machmur R, Heinke R, Trojer P, Bauer I, Brosch G, Schüle R, Hanefeld W, Sippl W, Jung M. Spannhoff A, et al. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4150-3. doi: 10.1016/j.bmcl.2007.05.088. Epub 2007 Jun 3. Bioorg Med Chem Lett. 2007. PMID: 17570663

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