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N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: design, synthesis, SAR studies, and in vivo antitumor activity.
Wang H, Yu N, Song H, Chen D, Zou Y, Deng W, Lye PL, Chang J, Ng M, Sun ET, Sangthongpitag K, Wang X, Wu X, Khng HH, Fang L, Goh SK, Ong WC, Bonday Z, Stünkel W, Poulsen A, Entzeroth M. Wang H, et al. Among authors: stunkel w. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1403-8. doi: 10.1016/j.bmcl.2009.01.041. Epub 2009 Jan 19. Bioorg Med Chem Lett. 2009. PMID: 19181524
Function of the SIRT1 protein deacetylase in cancer.
Stünkel W, Peh BK, Tan YC, Nayagam VM, Wang X, Salto-Tellez M, Ni B, Entzeroth M, Wood J. Stünkel W, et al. Biotechnol J. 2007 Nov;2(11):1360-8. doi: 10.1002/biot.200700087. Biotechnol J. 2007. PMID: 17806102
Sirtuin 1 (SIRT1): the misunderstood HDAC.
Stünkel W, Campbell RM. Stünkel W, et al. J Biomol Screen. 2011 Dec;16(10):1153-69. doi: 10.1177/1087057111422103. Epub 2011 Nov 15. J Biomol Screen. 2011. PMID: 22086720 Review.
51 results