Sawyers CL - Search Results

1

Histone deacetylases are required for androgen receptor function in hormone-sensitive and castrate-resistant prostate cancer.

Welsbie DS, Xu J, Chen Y, Borsu L, Scher HI, Rosen N, Sawyers CL. Welsbie DS, et al. Among authors: sawyers cl. Cancer Res. 2009 Feb 1;69(3):958-66. doi: 10.1158/0008-5472.CAN-08-2216. Epub 2009 Jan 27. Cancer Res. 2009. PMID: 19176386 Free PMC article.

2

A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase.

Craft N, Shostak Y, Carey M, Sawyers CL. Craft N, et al. Among authors: sawyers cl. Nat Med. 1999 Mar;5(3):280-5. doi: 10.1038/6495. Nat Med. 1999. PMID: 10086382

3

Mitogen-activated protein kinase kinase kinase 1 activates androgen receptor-dependent transcription and apoptosis in prostate cancer.

Abreu-Martin MT, Chari A, Palladino AA, Craft NA, Sawyers CL. Abreu-Martin MT, et al. Among authors: sawyers cl. Mol Cell Biol. 1999 Jul;19(7):5143-54. doi: 10.1128/MCB.19.7.5143. Mol Cell Biol. 1999. PMID: 10373563 Free PMC article.

4

Mechanistic concepts in androgen-dependence of prostate cancer.

Craft N, Sawyers CL. Craft N, et al. Among authors: sawyers cl. Cancer Metastasis Rev. 1998-1999;17(4):421-7. doi: 10.1023/a:1006141806801. Cancer Metastasis Rev. 1998. PMID: 10453286 Review.

5

Evidence for clonal outgrowth of androgen-independent prostate cancer cells from androgen-dependent tumors through a two-step process.

Craft N, Chhor C, Tran C, Belldegrun A, DeKernion J, Witte ON, Said J, Reiter RE, Sawyers CL. Craft N, et al. Among authors: sawyers cl. Cancer Res. 1999 Oct 1;59(19):5030-6. Cancer Res. 1999. PMID: 10519419

6

In vivo progression of LAPC-9 and LNCaP prostate cancer models to androgen independence is associated with increased expression of insulin-like growth factor I (IGF-I) and IGF-I receptor (IGF-IR).

Nickerson T, Chang F, Lorimer D, Smeekens SP, Sawyers CL, Pollak M. Nickerson T, et al. Among authors: sawyers cl. Cancer Res. 2001 Aug 15;61(16):6276-80. Cancer Res. 2001. PMID: 11507082

7

Growth inhibitory effects of the dual ErbB1/ErbB2 tyrosine kinase inhibitor PKI-166 on human prostate cancer xenografts.

Mellinghoff IK, Tran C, Sawyers CL. Mellinghoff IK, et al. Among authors: sawyers cl. Cancer Res. 2002 Sep 15;62(18):5254-9. Cancer Res. 2002. PMID: 12234993

8

BCR-ABL point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90.

Gorre ME, Ellwood-Yen K, Chiosis G, Rosen N, Sawyers CL. Gorre ME, et al. Among authors: sawyers cl. Blood. 2002 Oct 15;100(8):3041-4. doi: 10.1182/blood-2002-05-1361. Blood. 2002. PMID: 12351420 Free article.

9

A novel pyridopyrimidine inhibitor of abl kinase is a picomolar inhibitor of Bcr-abl-driven K562 cells and is effective against STI571-resistant Bcr-abl mutants.

Huron DR, Gorre ME, Kraker AJ, Sawyers CL, Rosen N, Moasser MM. Huron DR, et al. Among authors: sawyers cl. Clin Cancer Res. 2003 Apr;9(4):1267-73. Clin Cancer Res. 2003. PMID: 12684394

10

Analysis of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma patients in vivo.

Choe G, Horvath S, Cloughesy TF, Crosby K, Seligson D, Palotie A, Inge L, Smith BL, Sawyers CL, Mischel PS. Choe G, et al. Among authors: sawyers cl. Cancer Res. 2003 Jun 1;63(11):2742-6. Cancer Res. 2003. PMID: 12782577

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