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A novel, highly selective, tight binding IkappaB kinase-2 (IKK-2) inhibitor: a tool to correlate IKK-2 activity to the fate and functions of the components of the nuclear factor-kappaB pathway in arthritis-relevant cells and animal models.
Mbalaviele G, Sommers CD, Bonar SL, Mathialagan S, Schindler JF, Guzova JA, Shaffer AF, Melton MA, Christine LJ, Tripp CS, Chiang PC, Thompson DC, Hu Y, Kishore N. Mbalaviele G, et al. Among authors: sommers cd. J Pharmacol Exp Ther. 2009 Apr;329(1):14-25. doi: 10.1124/jpet.108.143800. Epub 2009 Jan 23. J Pharmacol Exp Ther. 2009. PMID: 19168710
Novel tight-binding inhibitory factor-kappaB kinase (IKK-2) inhibitors demonstrate target-specific anti-inflammatory activities in cellular assays and following oral and local delivery in an in vivo model of airway inflammation.
Sommers CD, Thompson JM, Guzova JA, Bonar SL, Rader RK, Mathialagan S, Venkatraman N, Holway VW, Kahn LE, Hu G, Garner DS, Huang HC, Chiang PC, Schindler JF, Hu Y, Meyer DM, Kishore NN. Sommers CD, et al. J Pharmacol Exp Ther. 2009 Aug;330(2):377-88. doi: 10.1124/jpet.108.147538. Epub 2009 May 28. J Pharmacol Exp Ther. 2009. PMID: 19478133
Aminopyridinecarboxamide-based inhibitors: Structure-activity relationship.
Bonafoux DF, Bonar SL, Clare M, Donnelly AM, Glaenzer JL, Guzova JA, Huang H, Kishore NN, Koszyk FJ, Lennon PJ, Libby A, Mathialagan S, Oburn DS, Rouw SA, Sommers CD, Tripp CS, Vanella LJ, Weier R, Wolfson SG, Huang HC. Bonafoux DF, et al. Among authors: sommers cd. Bioorg Med Chem. 2010 Jan 1;18(1):403-14. doi: 10.1016/j.bmc.2009.10.040. Epub 2009 Oct 27. Bioorg Med Chem. 2010. PMID: 19914076
Aminopyridinecarboxamide-based inhaled IKK-2 inhibitors for asthma and COPD: Structure-activity relationship.
Xie J, Poda GI, Hu Y, Chen NX, Heier RF, Wolfson SG, Reding MT, Lennon PJ, Kurumbail RG, Selness SR, Li X, Kishore NN, Sommers CD, Christine L, Bonar SL, Venkatraman N, Mathialagan S, Brustkern SJ, Huang HC. Xie J, et al. Among authors: sommers cd. Bioorg Med Chem. 2011 Feb 1;19(3):1242-55. doi: 10.1016/j.bmc.2010.12.027. Epub 2010 Dec 23. Bioorg Med Chem. 2011. PMID: 21236687
Inhibition of IKK-2 by 2-[(aminocarbonyl)amino]-5-acetylenyl-3-thiophenecarboxamides.
Bonafoux D, Bonar S, Christine L, Clare M, Donnelly A, Guzova J, Kishore N, Lennon P, Libby A, Mathialagan S, McGhee W, Rouw S, Sommers C, Tollefson M, Tripp C, Weier R, Wolfson S, Min Y. Bonafoux D, et al. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2870-5. doi: 10.1016/j.bmcl.2005.03.090. Bioorg Med Chem Lett. 2005. PMID: 15911271
36 results