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The peptide-binding activity of GRP94 is regulated by calcium.
Biswas C, Ostrovsky O, Makarewich CA, Wanderling S, Gidalevitz T, Argon Y. Biswas C, et al. Among authors: ostrovsky o. Biochem J. 2007 Jul 15;405(2):233-41. doi: 10.1042/BJ20061867. Biochem J. 2007. PMID: 17411420 Free PMC article.
Development of a Grp94 inhibitor.
Duerfeldt AS, Peterson LB, Maynard JC, Ng CL, Eletto D, Ostrovsky O, Shinogle HE, Moore DS, Argon Y, Nicchitta CV, Blagg BS. Duerfeldt AS, et al. Among authors: ostrovsky o. J Am Chem Soc. 2012 Jun 13;134(23):9796-804. doi: 10.1021/ja303477g. Epub 2012 May 29. J Am Chem Soc. 2012. PMID: 22642269 Free PMC article.
The mTOR inhibitor everolimus overcomes CXCR4-mediated resistance to histone deacetylase inhibitor panobinostat through inhibition of p21 and mitotic regulators.
Beider K, Bitner H, Voevoda-Dimenshtein V, Rosenberg E, Sirovsky Y, Magen H, Canaani J, Ostrovsky O, Shilo N, Shimoni A, Abraham M, Weiss L, Milyavsky M, Peled A, Nagler A. Beider K, et al. Among authors: ostrovsky o. Biochem Pharmacol. 2019 Oct;168:412-428. doi: 10.1016/j.bcp.2019.07.016. Epub 2019 Jul 17. Biochem Pharmacol. 2019. PMID: 31325448
Blocking of Transient Receptor Potential Vanilloid 1 (TRPV1) promotes terminal mitophagy in multiple myeloma, disturbing calcium homeostasis and targeting ubiquitin pathway and bortezomib-induced unfolded protein response.
Beider K, Rosenberg E, Dimenshtein-Voevoda V, Sirovsky Y, Vladimirsky J, Magen H, Ostrovsky O, Shimoni A, Bromberg Z, Weiss L, Peled A, Nagler A. Beider K, et al. Among authors: ostrovsky o. J Hematol Oncol. 2020 Nov 25;13(1):158. doi: 10.1186/s13045-020-00993-0. J Hematol Oncol. 2020. PMID: 33239060 Free PMC article.
49 results