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Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1.
Antony S, Marchand C, Stephen AG, Thibaut L, Agama KK, Fisher RJ, Pommier Y. Antony S, et al. Among authors: marchand c. Nucleic Acids Res. 2007;35(13):4474-84. doi: 10.1093/nar/gkm463. Epub 2007 Jun 18. Nucleic Acids Res. 2007. PMID: 17576665 Free PMC article.
Tyrosyl-DNA phosphodiesterase as a target for anticancer therapy.
Dexheimer TS, Antony S, Marchand C, Pommier Y. Dexheimer TS, et al. Among authors: marchand c. Anticancer Agents Med Chem. 2008 May;8(4):381-9. doi: 10.2174/187152008784220357. Anticancer Agents Med Chem. 2008. PMID: 18473723 Free PMC article. Review.
Inhibitors of human tyrosyl-DNA phospodiesterase (hTdp1) developed by virtual screening using ligand-based pharmacophores.
Weidlich IE, Dexheimer T, Marchand C, Antony S, Pommier Y, Nicklaus MC. Weidlich IE, et al. Among authors: marchand c. Bioorg Med Chem. 2010 Jan 1;18(1):182-9. doi: 10.1016/j.bmc.2009.11.008. Epub 2009 Nov 11. Bioorg Med Chem. 2010. Corrected and republished in: Bioorg Med Chem. 2010 Mar 15;18(6):2347-2355. doi: 10.1016/j.bmc.2010.02.009 PMID: 19963390 Free PMC article. Corrected and republished.
Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitors.
Huang SN, Pommier Y, Marchand C. Huang SN, et al. Among authors: marchand c. Expert Opin Ther Pat. 2011 Sep;21(9):1285-92. doi: 10.1517/13543776.2011.604314. Expert Opin Ther Pat. 2011. PMID: 21843105 Free PMC article. Review.
Biochemical assays for the discovery of TDP1 inhibitors.
Marchand C, Huang SY, Dexheimer TS, Lea WA, Mott BT, Chergui A, Naumova A, Stephen AG, Rosenthal AS, Rai G, Murai J, Gao R, Maloney DJ, Jadhav A, Jorgensen WL, Simeonov A, Pommier Y. Marchand C, et al. Mol Cancer Ther. 2014 Aug;13(8):2116-26. doi: 10.1158/1535-7163.MCT-13-0952. Epub 2014 Jul 14. Mol Cancer Ther. 2014. PMID: 25024006 Free PMC article.
Interfacial inhibitors of protein-nucleic acid interactions.
Pommier Y, Marchand C. Pommier Y, et al. Among authors: marchand c. Curr Med Chem Anticancer Agents. 2005 Jul;5(4):421-9. doi: 10.2174/1568011054222337. Curr Med Chem Anticancer Agents. 2005. PMID: 16101492 Review.
506 results