Dexheimer TS - Search Results

1

Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay.

Marchand C, Lea WA, Jadhav A, Dexheimer TS, Austin CP, Inglese J, Pommier Y, Simeonov A. Marchand C, et al. Among authors: dexheimer ts. Mol Cancer Ther. 2009 Jan;8(1):240-8. doi: 10.1158/1535-7163.MCT-08-0878. Mol Cancer Ther. 2009. PMID: 19139134 Free PMC article.

2

Nitrated indenoisoquinolines as topoisomerase I inhibitors: a systematic study and optimization.

Morrell A, Placzek M, Parmley S, Antony S, Dexheimer TS, Pommier Y, Cushman M. Morrell A, et al. Among authors: dexheimer ts. J Med Chem. 2007 Sep 6;50(18):4419-30. doi: 10.1021/jm070361q. Epub 2007 Aug 15. J Med Chem. 2007. PMID: 17696418

3

Novel E-ring camptothecin keto analogues (S38809 and S39625) are stable, potent, and selective topoisomerase I inhibitors without being substrates of drug efflux transporters.

Takagi K, Dexheimer TS, Redon C, Sordet O, Agama K, Lavielle G, Pierré A, Bates SE, Pommier Y. Takagi K, et al. Among authors: dexheimer ts. Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3229-38. doi: 10.1158/1535-7163.MCT-07-0441. Mol Cancer Ther. 2007. PMID: 18089716

4

Tyrosyl-DNA phosphodiesterase as a target for anticancer therapy.

Dexheimer TS, Antony S, Marchand C, Pommier Y. Dexheimer TS, et al. Anticancer Agents Med Chem. 2008 May;8(4):381-9. doi: 10.2174/187152008784220357. Anticancer Agents Med Chem. 2008. PMID: 18473723 Free PMC article. Review.

5

The modulation of topoisomerase I-mediated DNA cleavage and the induction of DNA-topoisomerase I crosslinks by crotonaldehyde-derived DNA adducts.

Dexheimer TS, Kozekova A, Rizzo CJ, Stone MP, Pommier Y. Dexheimer TS, et al. Nucleic Acids Res. 2008 Jul;36(12):4128-36. doi: 10.1093/nar/gkn334. Epub 2008 Jun 10. Nucleic Acids Res. 2008. PMID: 18550580 Free PMC article.

6

Design, synthesis, and biological evaluation of 14-substituted aromathecins as topoisomerase I inhibitors.

Cinelli MA, Morrell A, Dexheimer TS, Scher ES, Pommier Y, Cushman M. Cinelli MA, et al. Among authors: dexheimer ts. J Med Chem. 2008 Aug 14;51(15):4609-19. doi: 10.1021/jm800259e. Epub 2008 Jul 17. J Med Chem. 2008. PMID: 18630891 Free PMC article.

7

Par-4 binds to topoisomerase 1 and attenuates its DNA relaxation activity.

Goswami A, Qiu S, Dexheimer TS, Ranganathan P, Burikhanov R, Pommier Y, Rangnekar VM. Goswami A, et al. Among authors: dexheimer ts. Cancer Res. 2008 Aug 1;68(15):6190-8. doi: 10.1158/0008-5472.CAN-08-0831. Cancer Res. 2008. PMID: 18676842 Free PMC article.

8

DNA cleavage assay for the identification of topoisomerase I inhibitors.

Dexheimer TS, Pommier Y. Dexheimer TS, et al. Nat Protoc. 2008;3(11):1736-50. doi: 10.1038/nprot.2008.174. Nat Protoc. 2008. PMID: 18927559 Free PMC article.

9

Synthesis and biological evaluation of 14-(aminoalkyl-aminomethyl)aromathecins as topoisomerase I inhibitors: investigating the hypothesis of shared structure-activity relationships.

Cinelli MA, Cordero B, Dexheimer TS, Pommier Y, Cushman M. Cinelli MA, et al. Among authors: dexheimer ts. Bioorg Med Chem. 2009 Oct 15;17(20):7145-55. doi: 10.1016/j.bmc.2009.08.066. Epub 2009 Sep 6. Bioorg Med Chem. 2009. PMID: 19783447 Free PMC article.

10

Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK.

Das BB, Antony S, Gupta S, Dexheimer TS, Redon CE, Garfield S, Shiloh Y, Pommier Y. Das BB, et al. Among authors: dexheimer ts. EMBO J. 2009 Dec 2;28(23):3667-80. doi: 10.1038/emboj.2009.302. Epub 2009 Oct 22. EMBO J. 2009. PMID: 19851285 Free PMC article.

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