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Neutrophil elastase-initiated EGFR/MEK/ERK signaling counteracts stabilizing effect of autocrine TGF-beta on tropoelastin mRNA in lung fibroblasts.
DiCamillo SJ, Yang S, Panchenko MV, Toselli PA, Naggar EF, Rich CB, Stone PJ, Nugent MA, Panchenko MP. DiCamillo SJ, et al. Among authors: nugent ma. Am J Physiol Lung Cell Mol Physiol. 2006 Aug;291(2):L232-43. doi: 10.1152/ajplung.00530.2005. Epub 2006 Feb 10. Am J Physiol Lung Cell Mol Physiol. 2006. PMID: 16473861 Free article.
Besides its direct elastolytic activity, NE releases soluble epidermal growth factor receptor (EGFR) ligands and initiates EGFR/MEK/ERK signaling to downregulate tropoelastin mRNA in neonatal rat lung fibroblasts (DiCamillo SJ, Carreras I, Panchenko MV, Stone PJ, Nugent …
Besides its direct elastolytic activity, NE releases soluble epidermal growth factor receptor (EGFR) ligands and initiates EGFR/MEK/ERK sign …
Elastase mediates the release of growth factors from lung in vivo.
Buczek-Thomas JA, Lucey EC, Stone PJ, Chu CL, Rich CB, Carreras I, Goldstein RH, Foster JA, Nugent MA. Buczek-Thomas JA, et al. Among authors: nugent ma. Am J Respir Cell Mol Biol. 2004 Sep;31(3):344-50. doi: 10.1165/rcmb.2003-0420OC. Epub 2004 Jun 10. Am J Respir Cell Mol Biol. 2004. PMID: 15191913
112 results