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Antiprotealide is a natural product.
Manam RR, Macherla VR, Tsueng G, Dring CW, Weiss J, Neuteboom ST, Lam KS, Potts BC. Manam RR, et al. J Nat Prod. 2009 Feb 27;72(2):295-7. doi: 10.1021/np800578e. J Nat Prod. 2009. PMID: 19133779
Proteasome regulator marizomib (NPI-0052) exhibits prolonged inhibition, attenuated efflux, and greater cytotoxicity than its reversible analogs.
Obaidat A, Weiss J, Wahlgren B, Manam RR, Macherla VR, McArthur K, Chao TH, Palladino MA, Lloyd GK, Potts BC, Enna SJ, Neuteboom ST, Hagenbuch B. Obaidat A, et al. Among authors: manam rr. J Pharmacol Exp Ther. 2011 May;337(2):479-86. doi: 10.1124/jpet.110.177824. Epub 2011 Feb 8. J Pharmacol Exp Ther. 2011. PMID: 21303921 Free PMC article.