Tokita S - Search Results

1

Hemodynamic and cardiac neurotransmitter-releasing effects in conscious dogs of attention- and wake-promoting agents: a comparison of d-amphetamine, atomoxetine, modafinil, and a novel quinazolinone H3 inverse agonist.

Lynch J Jr, Regan C, Stump G, Tannenbaum P, Stevens J, Bone A, Gilberto D, Johnson C, Fujino N, Takenaga N, Tokita S, Nagase T, Sato N, Renger J. Lynch J Jr, et al. Among authors: tokita s. J Cardiovasc Pharmacol. 2009 Jan;53(1):52-9. doi: 10.1097/FJC.0b013e318195a470. J Cardiovasc Pharmacol. 2009. PMID: 19129736

2

Synthesis, structure-activity relationships, and biological profiles of a quinazolinone class of histamine H3 receptor inverse agonists.

Nagase T, Mizutani T, Ishikawa S, Sekino E, Sasaki T, Fujimura T, Ito S, Mitobe Y, Miyamoto Y, Yoshimoto R, Tanaka T, Ishihara A, Takenaga N, Tokita S, Fukami T, Sato N. Nagase T, et al. Among authors: tokita s. J Med Chem. 2008 Aug 14;51(15):4780-9. doi: 10.1021/jm8003834. Epub 2008 Jul 4. J Med Chem. 2008. PMID: 18598020

3

Synthesis and evaluation of structurally constrained quinazolinone derivatives as potent and selective histamine H3 receptor inverse agonists.

Nagase T, Mizutani T, Sekino E, Ishikawa S, Ito S, Mitobe Y, Miyamoto Y, Yoshimoto R, Tanaka T, Ishihara A, Takenaga N, Tokita S, Sato N. Nagase T, et al. Among authors: tokita s. J Med Chem. 2008 Nov 13;51(21):6889-901. doi: 10.1021/jm800569w. Epub 2008 Oct 8. J Med Chem. 2008. PMID: 18841880

4

Development of novel 2-[4-(aminoalkoxy)phenyl]-4(3H)-quinazolinone derivatives as potent and selective histamine H3 receptor inverse agonists.

Mizutani T, Nagase T, Ito S, Miyamoto Y, Tanaka T, Takenaga N, Tokita S, Sato N. Mizutani T, et al. Among authors: tokita s. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6041-5. doi: 10.1016/j.bmcl.2008.10.034. Epub 2008 Oct 11. Bioorg Med Chem Lett. 2008. PMID: 18952421

5

Synthesis and evaluation of a spiro-isobenzofuranone class of histamine H3 receptor inverse agonists.

Jitsuoka M, Tsukahara D, Ito S, Tanaka T, Takenaga N, Tokita S, Sato N. Jitsuoka M, et al. Among authors: tokita s. Bioorg Med Chem Lett. 2008 Sep 15;18(18):5101-6. doi: 10.1016/j.bmcl.2008.07.125. Epub 2008 Aug 5. Bioorg Med Chem Lett. 2008. PMID: 18768318

6

Inverse agonist histamine H3 receptor PET tracers labelled with carbon-11 or fluorine-18.

Hamill TG, Sato N, Jitsuoka M, Tokita S, Sanabria S, Eng W, Ryan C, Krause S, Takenaga N, Patel S, Zeng Z, Williams D Jr, Sur C, Hargreaves R, Burns HD. Hamill TG, et al. Among authors: tokita s. Synapse. 2009 Dec;63(12):1122-32. doi: 10.1002/syn.20689. Synapse. 2009. PMID: 19670309

7

Synthesis, structure-activity relationships, and biological profiles of a dihydrobenzoxathiin class of histamine H(3) receptor inverse agonists.

Sasaki T, Takahashi T, Nagase T, Mizutani T, Ito S, Mitobe Y, Miyamoto Y, Kanesaka M, Yoshimoto R, Tanaka T, Takenaga N, Tokita S, Sato N. Sasaki T, et al. Among authors: tokita s. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4232-6. doi: 10.1016/j.bmcl.2009.05.101. Epub 2009 May 30. Bioorg Med Chem Lett. 2009. PMID: 19520574

8

Development of a selective and potent radioactive ligand for histamine H(3) receptors: A compound potentially useful for receptor occupancy studies.

Mitobe Y, Ito S, Mizutani T, Nagase T, Sato N, Tokita S. Mitobe Y, et al. Among authors: tokita s. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4075-8. doi: 10.1016/j.bmcl.2009.06.025. Epub 2009 Jun 13. Bioorg Med Chem Lett. 2009. PMID: 19553110

9

Synthesis and biological evaluation of a novel 3-sulfonyl-8-azabicyclo[3.2.1]octane class of long chain fatty acid elongase 6 (ELOVL6) inhibitors.

Nagase T, Takahashi T, Sasaki T, Nagumo A, Shimamura K, Miyamoto Y, Kitazawa H, Kanesaka M, Yoshimoto R, Aragane K, Tokita S, Sato N. Nagase T, et al. Among authors: tokita s. J Med Chem. 2009 Jul 23;52(14):4111-4. doi: 10.1021/jm900488k. J Med Chem. 2009. PMID: 19522500

10

Synthesis and evaluation of a novel indoledione class of long chain fatty acid elongase 6 (ELOVL6) inhibitors.

Takahashi T, Nagase T, Sasaki T, Nagumo A, Shimamura K, Miyamoto Y, Kitazawa H, Kanesaka M, Yoshimoto R, Aragane K, Tokita S, Sato N. Takahashi T, et al. Among authors: tokita s. J Med Chem. 2009 May 28;52(10):3142-5. doi: 10.1021/jm900391x. J Med Chem. 2009. PMID: 19388647

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