Gegg C - Search Results

1

An acyl-ghrelin-specific neutralizing antibody inhibits the acute ghrelin-mediated orexigenic effects in mice.

Lu SC, Xu J, Chinookoswong N, Liu S, Steavenson S, Gegg C, Brankow D, Lindberg R, Véniant M, Gu W. Lu SC, et al. Among authors: gegg c. Mol Pharmacol. 2009 Apr;75(4):901-7. doi: 10.1124/mol.108.052852. Epub 2009 Jan 7. Mol Pharmacol. 2009. PMID: 19129426

2

Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo activity.

Miranda LP, Winters KA, Gegg CV, Patel A, Aral J, Long J, Zhang J, Diamond S, Guido M, Stanislaus S, Ma M, Li H, Rose MJ, Poppe L, Véniant MM. Miranda LP, et al. J Med Chem. 2008 May 8;51(9):2758-65. doi: 10.1021/jm701522b. Epub 2008 Apr 15. J Med Chem. 2008. PMID: 18412318

3

Discovery of the Migraine Prevention Therapeutic Aimovig (Erenumab), the First FDA-Approved Antibody against a G-Protein-Coupled Receptor.

King CT, Gegg CV, Hu SN, Sen Lu H, Chan BM, Berry KA, Brankow DW, Boone TJ, Kezunovic N, Kelley MR, Shi L, Xu C. King CT, et al. Among authors: gegg cv. ACS Pharmacol Transl Sci. 2019 Sep 3;2(6):485-490. doi: 10.1021/acsptsci.9b00061. eCollection 2019 Dec 13. ACS Pharmacol Transl Sci. 2019. PMID: 32259079 Free PMC article.

4

Identification of potent, selective, and metabolically stable peptide antagonists to the calcitonin gene-related peptide (CGRP) receptor.

Miranda LP, Holder JR, Shi L, Bennett B, Aral J, Gegg CV, Wright M, Walker K, Doellgast G, Rogers R, Li H, Valladares V, Salyers K, Johnson E, Wild K. Miranda LP, et al. J Med Chem. 2008 Dec 25;51(24):7889-97. doi: 10.1021/jm8009298. J Med Chem. 2008. PMID: 19053766

5

Investigation of the effects of altered receptor binding activity on the clearance of erythropoiesis-stimulating proteins: Nonerythropoietin receptor-mediated pathways may play a major role.

Agoram B, Aoki K, Doshi S, Gegg C, Jang G, Molineux G, Narhi L, Elliott S. Agoram B, et al. Among authors: gegg c. J Pharm Sci. 2009 Jun;98(6):2198-211. doi: 10.1002/jps.21578. J Pharm Sci. 2009. PMID: 18837016

6

Peptibodies: A flexible alternative format to antibodies.

Shimamoto G, Gegg C, Boone T, Quéva C. Shimamoto G, et al. Among authors: gegg c. MAbs. 2012 Sep-Oct;4(5):586-91. doi: 10.4161/mabs.21024. Epub 2012 Jul 23. MAbs. 2012. PMID: 22820181 Free PMC article. Review.

7

Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3.

Murray JK, Qian YX, Liu B, Elliott R, Aral J, Park C, Zhang X, Stenkilsson M, Salyers K, Rose M, Li H, Yu S, Andrews KL, Colombero A, Werner J, Gaida K, Sickmier EA, Miu P, Itano A, McGivern J, Gegg CV, Sullivan JK, Miranda LP. Murray JK, et al. Among authors: gegg cv. J Med Chem. 2015 Sep 10;58(17):6784-802. doi: 10.1021/acs.jmedchem.5b00495. Epub 2015 Aug 31. J Med Chem. 2015. PMID: 26288216

8

Peptide antagonists of the calcitonin gene-related peptide (CGRP) receptor with improved pharmacokinetics and pharmacodynamics.

Miranda LP, Shi L, Holder JR, Wright M, Gegg CV, Johnson E, Wild K, Stenkilsson M, Doellgast G, Manning BH, Salyers K. Miranda LP, et al. Biopolymers. 2013 Jul;100(4):422-30. doi: 10.1002/bip.22270. Biopolymers. 2013. PMID: 23868210

9

Ligand-binding mass spectrometry to study biotransformation of fusion protein drugs and guide immunoassay development: strategic approach and application to peptibodies targeting the thrombopoietin receptor.

Hall MP, Gegg C, Walker K, Spahr C, Ortiz R, Patel V, Yu S, Zhang L, Lu H, DeSilva B, Lee JW. Hall MP, et al. Among authors: gegg c. AAPS J. 2010 Dec;12(4):576-85. doi: 10.1208/s12248-010-9218-9. Epub 2010 Jul 13. AAPS J. 2010. PMID: 20625864 Free PMC article.

10

Interactions between PEG and type I soluble tumor necrosis factor receptor: modulation by pH and by PEGylation at the N terminus.

Kerwin BA, Chang BS, Gegg CV, Gonnelli M, Li T, Strambini GB. Kerwin BA, et al. Protein Sci. 2002 Jul;11(7):1825-33. doi: 10.1110/ps.0208102. Protein Sci. 2002. PMID: 12070334 Free PMC article.

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