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Page 1
Atomic view of a toxic amyloid small oligomer.
Laganowsky A, Liu C, Sawaya MR, Whitelegge JP, Park J, Zhao M, Pensalfini A, Soriaga AB, Landau M, Teng PK, Cascio D, Glabe C, Eisenberg D. Laganowsky A, et al. Among authors: pensalfini a. Science. 2012 Mar 9;335(6073):1228-31. doi: 10.1126/science.1213151. Science. 2012. PMID: 22403391 Free PMC article.
Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice.
Rasool S, Albay R 3rd, Martinez-Coria H, Breydo L, Wu J, Milton S, Misra S, Tran A, Pensalfini A, Laferla F, Kayed R, Glabe CG. Rasool S, et al. Among authors: pensalfini a. Mol Neurodegener. 2012 Aug 6;7:37. doi: 10.1186/1750-1326-7-37. Mol Neurodegener. 2012. PMID: 22866920 Free PMC article.
Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates.
Liu C, Zhao M, Jiang L, Cheng PN, Park J, Sawaya MR, Pensalfini A, Gou D, Berk AJ, Glabe CG, Nowick J, Eisenberg D. Liu C, et al. Among authors: pensalfini a. Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):20913-8. doi: 10.1073/pnas.1218792109. Epub 2012 Dec 3. Proc Natl Acad Sci U S A. 2012. PMID: 23213214 Free PMC article.
Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques.
Pensalfini A, Albay R 3rd, Rasool S, Wu JW, Hatami A, Arai H, Margol L, Milton S, Poon WW, Corrada MM, Kawas CH, Glabe CG. Pensalfini A, et al. Neurobiol Dis. 2014 Nov;71:53-61. doi: 10.1016/j.nbd.2014.07.011. Epub 2014 Aug 1. Neurobiol Dis. 2014. PMID: 25092575 Free PMC article.
33 results