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Ischemia-induced calpain activation causes eukaryotic (translation) initiation factor 4G1 (eIF4GI) degradation, protein synthesis inhibition, and neuronal death.
Vosler PS, Gao Y, Brennan CS, Yanagiya A, Gan Y, Cao G, Zhang F, Morley SJ, Sonenberg N, Bennett MV, Chen J. Vosler PS, et al. Among authors: yanagiya a. Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18102-7. doi: 10.1073/pnas.1112635108. Epub 2011 Oct 17. Proc Natl Acad Sci U S A. 2011. PMID: 22006312 Free PMC article.
Translational homeostasis via the mRNA cap-binding protein, eIF4E.
Yanagiya A, Suyama E, Adachi H, Svitkin YV, Aza-Blanc P, Imataka H, Mikami S, Martineau Y, Ronai ZA, Sonenberg N. Yanagiya A, et al. Mol Cell. 2012 Jun 29;46(6):847-58. doi: 10.1016/j.molcel.2012.04.004. Epub 2012 May 10. Mol Cell. 2012. PMID: 22578813 Free PMC article.
57 results