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Next generation of adeno-associated virus 2 vectors: point mutations in tyrosines lead to high-efficiency transduction at lower doses.
Zhong L, Li B, Mah CS, Govindasamy L, Agbandje-McKenna M, Cooper M, Herzog RW, Zolotukhin I, Warrington KH Jr, Weigel-Van Aken KA, Hobbs JA, Zolotukhin S, Muzyczka N, Srivastava A. Zhong L, et al. Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7827-32. doi: 10.1073/pnas.0802866105. Epub 2008 May 29. Proc Natl Acad Sci U S A. 2008. PMID: 18511559 Free PMC article.
Optimized adeno-associated virus (AAV)-protein phosphatase-5 helper viruses for efficient liver transduction by single-stranded AAV vectors: therapeutic expression of factor IX at reduced vector doses.
Jayandharan GR, Zhong L, Sack BK, Rivers AE, Li M, Li B, Herzog RW, Srivastava A. Jayandharan GR, et al. Among authors: zhong l. Hum Gene Ther. 2010 Mar;21(3):271-83. doi: 10.1089/hum.2009.100. Hum Gene Ther. 2010. PMID: 19788390 Free PMC article.
Abstract Our studies have shown that coinjection of conventional single-stranded adeno-associated virus 2 (ssAAV2) vectors carrying the enhanced green fluorescent protein (EGFP) gene with self-complementary (sc) AAV2-T cell protein tyrosine phosphatase (TC-PTP) and scAAV2-protein …
Abstract Our studies have shown that coinjection of conventional single-stranded adeno-associated virus 2 (ssAAV2) vectors carrying the enha …
Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina.
Petrs-Silva H, Dinculescu A, Li Q, Deng WT, Pang JJ, Min SH, Chiodo V, Neeley AW, Govindasamy L, Bennett A, Agbandje-McKenna M, Zhong L, Li B, Jayandharan GR, Srivastava A, Lewin AS, Hauswirth WW. Petrs-Silva H, et al. Among authors: zhong l. Mol Ther. 2011 Feb;19(2):293-301. doi: 10.1038/mt.2010.234. Epub 2010 Nov 2. Mol Ther. 2011. PMID: 21045809 Free PMC article.
6,205 results