Nebert DW - Search Results

1

Knock-in mouse lines expressing either mitochondrial or microsomal CYP1A1: differing responses to dietary benzo[a]pyrene as proof of principle.

Dong H, Dalton TP, Miller ML, Chen Y, Uno S, Shi Z, Shertzer HG, Bansal S, Avadhani NG, Nebert DW. Dong H, et al. Among authors: nebert dw. Mol Pharmacol. 2009 Mar;75(3):555-67. doi: 10.1124/mol.108.051888. Epub 2008 Dec 1. Mol Pharmacol. 2009. PMID: 19047483 Free PMC article.

2

Balancer-Cre transgenic mouse germ cells direct the incomplete resolution of a tri-loxP-targeted Cyp1a1 allele, producing a conditional knockout allele.

Uno S, Wang B, Shertzer HG, Nebert DW, Dalton TP. Uno S, et al. Among authors: nebert dw. Biochem Biophys Res Commun. 2003 Dec 12;312(2):494-9. doi: 10.1016/j.bbrc.2003.10.145. Biochem Biophys Res Commun. 2003. PMID: 14637164

3

Cyp1a1(-/-) male mice: protection against high-dose TCDD-induced lethality and wasting syndrome, and resistance to intrahepatocyte lipid accumulation and uroporphyria.

Uno S, Dalton TP, Sinclair PR, Gorman N, Wang B, Smith AG, Miller ML, Shertzer HG, Nebert DW. Uno S, et al. Among authors: nebert dw. Toxicol Appl Pharmacol. 2004 May 1;196(3):410-21. doi: 10.1016/j.taap.2004.01.014. Toxicol Appl Pharmacol. 2004. PMID: 15094312

4

Oral exposure to benzo[a]pyrene in the mouse: detoxication by inducible cytochrome P450 is more important than metabolic activation.

Uno S, Dalton TP, Derkenne S, Curran CP, Miller ML, Shertzer HG, Nebert DW. Uno S, et al. Among authors: nebert dw. Mol Pharmacol. 2004 May;65(5):1225-37. doi: 10.1124/mol.65.5.1225. Mol Pharmacol. 2004. PMID: 15102951

5

Theophylline pharmacokinetics: comparison of Cyp1a1(-/-) and Cyp1a2(-/-) knockout mice, humanized hCYP1A1_1A2 knock-in mice lacking either the mouse Cyp1a1 or Cyp1a2 gene, and Cyp1(+/+) wild-type mice.

Derkenne S, Curran CP, Shertzer HG, Dalton TP, Dragin N, Nebert DW. Derkenne S, et al. Among authors: nebert dw. Pharmacogenet Genomics. 2005 Jul;15(7):503-11. doi: 10.1097/01.fpc.0000167326.00411.50. Pharmacogenet Genomics. 2005. PMID: 15970798

6

Oral benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate.

Uno S, Dalton TP, Dragin N, Curran CP, Derkenne S, Miller ML, Shertzer HG, Gonzalez FJ, Nebert DW. Uno S, et al. Among authors: nebert dw. Mol Pharmacol. 2006 Apr;69(4):1103-14. doi: 10.1124/mol.105.021501. Epub 2005 Dec 23. Mol Pharmacol. 2006. PMID: 16377763

7

Comparison of mouse hepatic mitochondrial versus microsomal cytochromes P450 following TCDD treatment.

Genter MB, Clay CD, Dalton TP, Dong H, Nebert DW, Shertzer HG. Genter MB, et al. Among authors: nebert dw. Biochem Biophys Res Commun. 2006 Apr 21;342(4):1375-81. doi: 10.1016/j.bbrc.2006.02.121. Epub 2006 Feb 28. Biochem Biophys Res Commun. 2006. PMID: 16516144

8

For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential.

Dragin N, Dalton TP, Miller ML, Shertzer HG, Nebert DW. Dragin N, et al. Among authors: nebert dw. J Biol Chem. 2006 Jul 7;281(27):18591-600. doi: 10.1074/jbc.M601159200. Epub 2006 Apr 24. J Biol Chem. 2006. PMID: 16636061 Free article.

9

7H-dibenzo[c,g]carbazole metabolism by the mouse and human CYP1 family of enzymes.

Shertzer HG, Genter MB, Talaska G, Curran CP, Nebert DW, Dalton TP. Shertzer HG, et al. Among authors: nebert dw. Carcinogenesis. 2007 Jun;28(6):1371-8. doi: 10.1093/carcin/bgl244. Epub 2006 Dec 13. Carcinogenesis. 2007. PMID: 17166882

10

Generation of 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-) mouse line.

Dragin N, Uno S, Wang B, Dalton TP, Nebert DW. Dragin N, et al. Among authors: nebert dw. Biochem Biophys Res Commun. 2007 Aug 3;359(3):635-42. doi: 10.1016/j.bbrc.2007.05.202. Epub 2007 Jun 6. Biochem Biophys Res Commun. 2007. PMID: 17560947 Free PMC article.

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